| Gene Symbol |
HEY2
|
| Entrez Gene |
23493
|
| Alt Symbol |
CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hes-related family bHLH transcription factor with YRPW motif 2
|
| Other Description |
HES-related repressor protein 1|HES-related repressor protein 2|HESR-2|HRT-2|cardiovascular basic helix-loop-helix factor 1|cardiovascular helix-loop-helix factor 1|class B basic helix-loop-helix protein 32|hCHF1|hHRT2|hairy and enhancer of split-related protein 2|hairy-related transcription factor 2|hairy/enhancer-of-split related with YRPW motif 2|hairy/enhancer-of-split related with YRPW motif protein 2|protein gridlock homolog
|
| Swissprots |
Q9UBP5
|
| Accessions |
EAW48135 Q9UBP5 AB044755 BAA96781 AF173901 AAF20173 AF232238 AAF37296 AF237949 AAF44781 AF311884 AAG31157 AJ249545 CAB56839 AK289943 BAF82632 AK303890 BAG64825 BC007707 AAH07707 BI549391 BT020067 AAV38870 BT020068 AAV38871 XM_005266878 XP_005266935 XM_011535649 XP_011533951 XM_011535650 XP_011533952 NM_012259 NP_036391
|
| Function |
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
|