Gene Symbol | HEY2 |
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Entrez Gene | 23493 |
Alt Symbol | CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32 |
Species | Human |
Gene Type | protein-coding |
Description | hes-related family bHLH transcription factor with YRPW motif 2 |
Other Description | HES-related repressor protein 1|HES-related repressor protein 2|HESR-2|HRT-2|cardiovascular basic helix-loop-helix factor 1|cardiovascular helix-loop-helix factor 1|class B basic helix-loop-helix protein 32|hCHF1|hHRT2|hairy and enhancer of split-related protein 2|hairy-related transcription factor 2|hairy/enhancer-of-split related with YRPW motif 2|hairy/enhancer-of-split related with YRPW motif protein 2|protein gridlock homolog |
Swissprots | Q9UBP5 |
Accessions | EAW48135 Q9UBP5 AB044755 BAA96781 AF173901 AAF20173 AF232238 AAF37296 AF237949 AAF44781 AF311884 AAG31157 AJ249545 CAB56839 AK289943 BAF82632 AK303890 BAG64825 BC007707 AAH07707 BI549391 BT020067 AAV38870 BT020068 AAV38871 XM_005266878 XP_005266935 XM_011535649 XP_011533951 XM_011535650 XP_011533952 NM_012259 NP_036391 |
Function | Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}. |
HRT2 CRISPR/Cas9 KO Plasmid (h) - sc-404761 from Santa Cruz Biotechnology
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HRT2 HDR Plasmid (h) - sc-404761-HDR from Santa Cruz Biotechnology
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HRT2 Double Nickase Plasmid (h) - sc-404761-NIC from Santa Cruz Biotechnology
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HRT2 Double Nickase Plasmid (h2) - sc-404761-NIC-2 from Santa Cruz Biotechnology
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HRT2 CRISPR Activation Plasmid (h) - sc-404761-ACT from Santa Cruz Biotechnology
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HRT2 CRISPR Activation Plasmid (h2) - sc-404761-ACT-2 from Santa Cruz Biotechnology
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HRT2 Lentiviral Activation Particles (h) - sc-404761-LAC from Santa Cruz Biotechnology
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HRT2 Lentiviral Activation Particles (h2) - sc-404761-LAC-2 from Santa Cruz Biotechnology
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HRT2 siRNA (h) - sc-37916 from Santa Cruz Biotechnology
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HRT2 shRNA Plasmid (h) - sc-37916-SH from Santa Cruz Biotechnology
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HRT2 shRNA (h) Lentiviral Particles - sc-37916-V from Santa Cruz Biotechnology
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HEY2 RNAi - H00023493-R01 from Novus Biologicals
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MISSION® esiRNA - EHU022391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10006 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10006 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09429 from Sigma-Aldrich
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HEY2 siRNA (Human) - CRH8304 from Cohesion Biosciences
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HEY2 - MBS8201774 from MyBioSource
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shRNA set against Human HEY2 (NM_012259.2) - SHH311837 from Creative biogene
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shRNA set against Human HEY2(NM_012259.2) - SHH119369 from Creative biogene
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HEY2 shRNA Plasmid (Human) - CHH8304 from Cohesion Biosciences
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HEY2 miRNA 3'UTR clone - MiUTR1H-04474 from Creative biogene
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