PRLR

Gene Symbol	PRLR
Entrez Gene	5618
Alt Symbol	HPRL, MFAB, hPRLrI
Species	Human
Gene Type	protein-coding
Description	prolactin receptor
Other Description	hPRL receptor|secreted prolactin binding protein
Swissprots	P16471 Q96P35 Q8TD75 D1MDP1 Q8TD78 Q96P36 B2R882 Q16354 Q9UHJ5 Q9BX87
Accessions	AAB33685 AAD32032 AAO73538 EAW55913 EAW55914 EAW55915 EAW55916 EAW55917 EAW55918 EAW55919 P16471 AF166329 AAD49855 AF349939 AAK32703 AF416618 AAL23914 AF416619 AAL23915 AF492470 AAM18048 AF493068 AAM11660 AF493069 AAM11661 AF512796 AI022810 AI041980 AI079645 AK001889 AK023665 AK313270 BAG36079 AM393450 CAL38328 AM393574 CAL38451 AY062295 AAL40855 BC059392 AAH59392 BP357907 BQ023302 BX538149 DA640476 GU133399 ACZ04321 KJ608382 KJ608383 KJ651922 AJA40019 KJ651923 AJA40020 KJ651924 AJA40021 KJ651925 AJA40022 M31661 AAA60174 S78505 AAB34470 XM_006714484 XP_006714547 XM_011514068 XP_011512370 XM_011514069 XP_011512371 NM_000949 NP_000940 NM_001204314 NP_001191243 NM_001204315 NP_001191244 NM_001204316 NP_001191245 NM_001204317 NP_001191246 NM_001204318 NP_001191247 NR_037910
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.
Subcellular Location	Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Prolactin signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRLR 293T Cell Transient Overexpression Lysate(Denatured) - H00005618-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRLR overexpression lysate - LY424444 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRLR 293 Cell Lysate - 410103 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PRLR Over-expression Lysate Product - GWB-F465C0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PRLR / Prolactin Receptor HEK293 Cell Lysate (WB positive control) - 10278-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PRLR Human Cells Transfected Lysate (positive control) (denatured) - orb173125 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Prolactin R Overexpression Lysate (Native) - NBP2-10720 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Prolactin R Overexpression Lysate (Denatured) - H00005618-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human PRLR Knockdown Stable Cell Line - CSC-DC012420 from Creative biogene Category Cell Line Species Human

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