PRLR

Gene Symbol	PRLR
Entrez Gene	5618
Alt Symbol	HPRL, MFAB, hPRLrI
Species	Human
Gene Type	protein-coding
Description	prolactin receptor
Other Description	hPRL receptor|secreted prolactin binding protein
Swissprots	P16471 Q96P35 Q8TD75 D1MDP1 Q8TD78 Q96P36 B2R882 Q16354 Q9UHJ5 Q9BX87
Accessions	AAB33685 AAD32032 AAO73538 EAW55913 EAW55914 EAW55915 EAW55916 EAW55917 EAW55918 EAW55919 P16471 AF166329 AAD49855 AF349939 AAK32703 AF416618 AAL23914 AF416619 AAL23915 AF492470 AAM18048 AF493068 AAM11660 AF493069 AAM11661 AF512796 AI022810 AI041980 AI079645 AK001889 AK023665 AK313270 BAG36079 AM393450 CAL38328 AM393574 CAL38451 AY062295 AAL40855 BC059392 AAH59392 BP357907 BQ023302 BX538149 DA640476 GU133399 ACZ04321 KJ608382 KJ608383 KJ651922 AJA40019 KJ651923 AJA40020 KJ651924 AJA40021 KJ651925 AJA40022 M31661 AAA60174 S78505 AAB34470 XM_006714484 XP_006714547 XM_011514068 XP_011512370 XM_011514069 XP_011512371 NM_000949 NP_000940 NM_001204314 NP_001191243 NM_001204315 NP_001191244 NM_001204316 NP_001191245 NM_001204317 NP_001191246 NM_001204318 NP_001191247 NR_037910
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.
Subcellular Location	Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Prolactin signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse Prolactin Receptor protein fragment - ab170084 from Abcam Category Protein Prices $302.00 Sizes 100 µg Source Insect cells Species Mouse

Active rabbit Prolactin Receptor protein fragment - ab73248 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Rabbit

Active rat Prolactin Receptor protein fragment - ab170083 from Abcam Category Protein Prices $302.00 Sizes 100 µg Source Insect cells Species Rat

Active rat Prolactin Receptor protein fragment - ab185247 from Abcam Category Protein Prices $405.00 Sizes 20 µg Source E. coli Species Rat

Cow Prolactin Receptor protein fragment - ab73249 from Abcam Category Protein Source E. coli Species Bovine

Human Prolactin Receptor peptide - ab98251 from Abcam Category Peptide

Recombinant Human Prolactin R Protein - H00005618-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Prolactin R Partial Recombinant Protein - H00005618-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Prolactin R Recombinant Protein - P4179 from Novus Biologicals Category Protein Prices $669.00 Sizes 20 µg Species Human

Recombinant Human Prolactin R Protein - NBP1-99553 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E. coli Species Human

Recombinant Human Prolactin R Fc Chimera, CF - 1167-PR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Rat Prolactin R Fc Chimera, CF - 1112-PR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

PRL R Protein (OPPA00728) - OPPA00728 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

PRL R Protein (OPPA01603) - OPPA01603 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

SYNTHETIC Human PROLACTIN RECEPTOR Protein (OPSA10592) - OPSA10592 from Aviva Systems Biology Category Protein Prices $145.00 Sizes 50 µg Species Human

Rat Prolactin Receptor protein - orb84763 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Rat Species Human

Human Prolactin Receptor protein - orb83264 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Prolactin Receptor protein - 30R-2805 from Fitzgerald Category Protein Prices $355.00 Sizes 50 µg Source E.coli Species Human

Prolactin Receptor protein - 30R-2803 from Fitzgerald Category Protein Prices $265.00 Sizes 20 µg Source E.coli Species Human

Prolactin receptor - H00005618-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Prolactin receptor - H00005618-P02-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Prolactin receptor - H00005618-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Prolactin receptor - H00005618-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Prolactin receptor - P4179 from Acris Antibodies Category Protein Prices $500.00 Sizes 20 µg Species Human

Recombinant Human Prolactin Receptor - 230-00621-10 from RayBiotech Category Protein Prices $107.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

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