PRLR

Gene Symbol PRLR
Entrez Gene 5618
Alt Symbol HPRL, MFAB, hPRLrI
Species Human
Gene Type protein-coding
Description prolactin receptor
Other Description hPRL receptor|secreted prolactin binding protein
Swissprots P16471 Q96P35 Q8TD75 D1MDP1 Q8TD78 Q96P36 B2R882 Q16354 Q9UHJ5 Q9BX87
Accessions AAB33685 AAD32032 AAO73538 EAW55913 EAW55914 EAW55915 EAW55916 EAW55917 EAW55918 EAW55919 P16471 AF166329 AAD49855 AF349939 AAK32703 AF416618 AAL23914 AF416619 AAL23915 AF492470 AAM18048 AF493068 AAM11660 AF493069 AAM11661 AF512796 AI022810 AI041980 AI079645 AK001889 AK023665 AK313270 BAG36079 AM393450 CAL38328 AM393574 CAL38451 AY062295 AAL40855 BC059392 AAH59392 BP357907 BQ023302 BX538149 DA640476 GU133399 ACZ04321 KJ608382 KJ608383 KJ651922 AJA40019 KJ651923 AJA40020 KJ651924 AJA40021 KJ651925 AJA40022 M31661 AAA60174 S78505 AAB34470 XM_006714484 XP_006714547 XM_011514068 XP_011512370 XM_011514069 XP_011512371 NM_000949 NP_000940 NM_001204314 NP_001191243 NM_001204315 NP_001191244 NM_001204316 NP_001191245 NM_001204317 NP_001191246 NM_001204318 NP_001191247 NR_037910
Function This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.
Subcellular Location Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Tissue Specificity Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Prolactin signaling pathway, Neuroactive ligand-receptor interaction

Prolactin Receptor (D4A9) Rabbit mAb - 13552 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4A9
Western blot analysis of extracts from various cell lines using Prolactin Receptor (D4A9) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

PRL-R (B10) - sc-74520 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRL-R (B10): sc-74520. Western blot analysis of mouse recombinant PRL-R.

PRL-R (H-300) - sc-20992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRL-R (H-300): sc-20992. Western blot analysis of PRL-R expression in 293T whole cell lysate.

PRL-R (G-20) - sc-34516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRL-R (M-170) - sc-30225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRL-R (M-170): sc-30225. Western blot analysis of mouse recombinant PRL-R.

PRL-R (E-20) - sc-21816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Prolactin Receptor antibody - ab87992 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Prolactin Receptor antibody (ab87992) at 1 µg/mlLane 1 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 3 : Breast (Human) Tissue Lysate - normal tissue (ab30090)Lane 4 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Prolactin Receptor antibody - ab89215 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Prolactin Receptor antibody (ab89215) at 5 µg/ml + Partial tagged recombinant Human Prolactin Receptor protein at 0.2 µg

Anti-Prolactin Receptor antibody - ab96714 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Prolactin Receptor antibody (ab96714) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-Prolactin Receptor antibody - ab35349 from Abcam

Prices $359.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-Prolactin Receptor antibody [5601] - ab81873 from Abcam

Prices $368.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 5601

Anti-Prolactin Receptor antibody [B6.2] - ab80565 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone B6.2
Formalin fixed, paraffin embedded human breast cancer stained with ab80565 at 2 µg/ml. Peroxidase conjugate and AEC chromogen were used. Note cell membrane and cytoplasmic staining of tumor cells.

Anti-Prolactin Receptor antibody [B6.2], prediluted - ab74608 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone B6.2
Prolactin receptor at 1ug/ml in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue using peroxidase-conjugate and AEC chromogen. Note cell membrane and cytoplasmic staining of tumor cells.

Anti-Prolactin Receptor antibody [B6.2 + PRLR742] - ab199015 from Abcam

Prices $373.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone B6.2 + PRLR742

Anti-Prolactin Receptor antibody [EPR7184(2)] - ab170935 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7184(2)
All lanes : Anti-Prolactin Receptor antibody [EPR7184(2)] (ab170935) at 1/1000 dilutionLane 1 : T47-D cell lysatesLane 2 : A431 cell lysatesLane 3 : Jurkat cell lysatesLysates/proteins at 10 µg per lane.

Anti-Prolactin Receptor antibody [EPR7184(2)] (Alexa Fluor® 488) - ab201760 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7184(2)
ab201760 staining Prolactin Recoptor in Jurkat cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201760 at 1/50 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Prolactin Receptor antibody [SPM213], prediluted - ab17831 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM213
Human breast cancer stained with anti-Prolactin Receptor, ab17831.

Anti-Prolactin Receptor antibody [T6] - ab2773 from Abcam

Prices $391.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone T6
Immunocytochemistry/Immunofluorescence analysis of Prolactin Receptor in C6 cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were incbated without (control) or with ab2773 (1:200) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. Prolactin Receptor staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.

Anti-PRLR / Prolactin Receptor Antibody (aa20-229, Biotin) - LS-C301192 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRLR / Prolactin Receptor Antibody - LS-C348201 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRLR / Prolactin Receptor Antibody (aa25-29) - LS-C205111 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of extracts from 293T cells expressing human PRLR protein using PRLR antibody.

Anti-PRLR / Prolactin Receptor Antibody (aa1-271) - LS-C185512 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A:293T, B: HeLa. 7.5% SDS PAGE. PRLR / Prolactin Receptor antibody diluted at 1:1000.

Anti-PRLR / Prolactin Receptor Antibody (aa254-303) - LS-C205742 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRLR / Prolactin Receptor antibody Western Blot of Lymph Node Tumor. Antibody dilution: 1 ug/ml.

Anti-PRLR / Prolactin Receptor Antibody (aa20-229) - LS-C296049 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PRLR / Prolactin Receptor.

Anti-PRLR / Prolactin Receptor Antibody (aa20-229) - LS-C150304 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Prolactin R in Rat Thymus. Prolactin R was detected in perfusion fixed frozen sections of rat thymus using Goat Anti-Rat Prolactin R Antigen Affinity-purified Polyclonal Antibody at 15 ug/ml overnight at 4°C. Tissue was stained using Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of lymphocytes.
Search more