PRLR

Gene Symbol	PRLR
Entrez Gene	5618
Alt Symbol	HPRL, MFAB, hPRLrI
Species	Human
Gene Type	protein-coding
Description	prolactin receptor
Other Description	hPRL receptor|secreted prolactin binding protein
Swissprots	P16471 Q96P35 Q8TD75 D1MDP1 Q8TD78 Q96P36 B2R882 Q16354 Q9UHJ5 Q9BX87
Accessions	AAB33685 AAD32032 AAO73538 EAW55913 EAW55914 EAW55915 EAW55916 EAW55917 EAW55918 EAW55919 P16471 AF166329 AAD49855 AF349939 AAK32703 AF416618 AAL23914 AF416619 AAL23915 AF492470 AAM18048 AF493068 AAM11660 AF493069 AAM11661 AF512796 AI022810 AI041980 AI079645 AK001889 AK023665 AK313270 BAG36079 AM393450 CAL38328 AM393574 CAL38451 AY062295 AAL40855 BC059392 AAH59392 BP357907 BQ023302 BX538149 DA640476 GU133399 ACZ04321 KJ608382 KJ608383 KJ651922 AJA40019 KJ651923 AJA40020 KJ651924 AJA40021 KJ651925 AJA40022 M31661 AAA60174 S78505 AAB34470 XM_006714484 XP_006714547 XM_011514068 XP_011512370 XM_011514069 XP_011512371 NM_000949 NP_000940 NM_001204314 NP_001191243 NM_001204315 NP_001191244 NM_001204316 NP_001191245 NM_001204317 NP_001191246 NM_001204318 NP_001191247 NR_037910
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.
Subcellular Location	Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Prolactin signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Prolactin Receptor siRNA I - 13822 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® Prolactin Receptor siRNA II - 13836 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

PRL-R CRISPR/Cas9 KO Plasmid (h) - sc-400814 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R HDR Plasmid (h) - sc-400814-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R Double Nickase Plasmid (h) - sc-400814-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R Double Nickase Plasmid (h2) - sc-400814-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R CRISPR Activation Plasmid (h) - sc-400814-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R CRISPR Activation Plasmid (h2) - sc-400814-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R Lentiviral Activation Particles (h) - sc-400814-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R Lentiviral Activation Particles (h2) - sc-400814-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRL-R siRNA (h) - sc-40167 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRL-R shRNA Plasmid (h) - sc-40167-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRL-R shRNA (h) Lentiviral Particles - sc-40167-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Prolactin R RNAi - H00005618-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU095011 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17437 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17437 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07914 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07914

PRLR siRNA (Human) - CRH3785 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PRLR (NM_000949.5) - SHH383260 from Creative biogene Category siRNA Species Reactivities Human

PRLR shRNA Plasmid (Human) - CHH3785 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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