| Gene Symbol |
AMIGO2
|
| Entrez Gene |
347902
|
| Alt Symbol |
ALI1, AMIGO-2, DEGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adhesion molecule with Ig-like domain 2
|
| Other Description |
alivin 1|amphoterin induced gene 2|amphoterin-induced protein 2|differentially expressed in gastric adenocarcinoma|differentially expressed in gastric adenocarcinomas|transmembrane protein AMIGO2
|
| Swissprots |
Q96CN8 Q4VBP6 Q86SJ2 Q7Z4A0
|
| Accessions |
CCF77052 EAW57923 EAW57924 Q86SJ2 AB079074 BAC81188 AB080610 BAC81189 AK091761 BAG52413 AK093111 BAG52657 AL833007 CAH56293 AY237005 AAO48946 AY454159 AAR83271 BC014103 AAH14103 BC047595 AAH47595 BC095477 AAH95477 CN397638 XM_005268837 XP_005268894 NM_001143668 NP_001137140 NM_181847 NP_862830
|
| Function |
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. {ECO:0000269|PubMed:15107827}.
|
![Western Blot: AMIGO2 Overexpression Lysate (Adult Normal) [NBL1-07501] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMIGO2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1488_AMIGO2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07501-img0002.jpg)
![Western Blot: AMIGO2 Overexpression Lysate (Adult Normal) [NBP2-09677] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMIGO2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5415_AMIGO2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09677-img0001.jpg)