| Gene Symbol | AMIGO2 |
|---|---|
| Entrez Gene | 347902 |
| Alt Symbol | ALI1, AMIGO-2, DEGA |
| Species | Human |
| Gene Type | protein-coding |
| Description | adhesion molecule with Ig-like domain 2 |
| Other Description | alivin 1|amphoterin induced gene 2|amphoterin-induced protein 2|differentially expressed in gastric adenocarcinoma|differentially expressed in gastric adenocarcinomas|transmembrane protein AMIGO2 |
| Swissprots | Q96CN8 Q4VBP6 Q86SJ2 Q7Z4A0 |
| Accessions | CCF77052 EAW57923 EAW57924 Q86SJ2 AB079074 BAC81188 AB080610 BAC81189 AK091761 BAG52413 AK093111 BAG52657 AL833007 CAH56293 AY237005 AAO48946 AY454159 AAR83271 BC014103 AAH14103 BC047595 AAH47595 BC095477 AAH95477 CN397638 XM_005268837 XP_005268894 NM_001143668 NP_001137140 NM_181847 NP_862830 |
| Function | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. {ECO:0000269|PubMed:15107827}. |