| Gene Symbol |
TAF8
|
| Entrez Gene |
129685
|
| Alt Symbol |
43, II, TAF, TAFII-43, TAFII43, TBN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
|
| Other Description |
TAF(II)43|TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa|TBP-associated factor 43 kDa|TBP-associated factor 8|TBP-associated factor TAFII43|TBP-associated factor, RNA polymerase II, 43 kD|hTAFII43|protein taube nuss|taube nuss homolog|transcription initiation factor TFIID 43 kDa subunit|transcription initiation factor TFIID subunit 8
|
| Swissprots |
Q96M52 Q5T0K1 Q7Z7C8 Q8N4R9
|
| Accessions |
EAX04078 EAX04079 EAX04080 Q7Z7C8 AF086309 AF465841 AAP47094 AK057383 BAB71460 AK303097 BAG64207 AL833401 BC018796 BC033728 BC119678 AAI19679 BC119679 AAI19680 BI828714 XM_005248849 XP_005248906 XM_011514296 XP_011512598 XM_011514297 XP_011512599 NM_138572 NP_612639
|
| Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14580349}. Cytoplasm {ECO:0000250}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.
|
| Top Pathways |
Basal transcription factors
|
![Western Blot: TAF8 Overexpression Lysate (Adult Normal) [NBP2-05644] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TAF8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10065_TAF8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05644-img0001.jpg)