| Gene Symbol | TAF8 |
|---|---|
| Entrez Gene | 129685 |
| Alt Symbol | 43, II, TAF, TAFII-43, TAFII43, TBN |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
| Other Description | TAF(II)43|TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa|TBP-associated factor 43 kDa|TBP-associated factor 8|TBP-associated factor TAFII43|TBP-associated factor, RNA polymerase II, 43 kD|hTAFII43|protein taube nuss|taube nuss homolog|transcription initiation factor TFIID 43 kDa subunit|transcription initiation factor TFIID subunit 8 |
| Swissprots | Q96M52 Q5T0K1 Q7Z7C8 Q8N4R9 |
| Accessions | EAX04078 EAX04079 EAX04080 Q7Z7C8 AF086309 AF465841 AAP47094 AK057383 BAB71460 AK303097 BAG64207 AL833401 BC018796 BC033728 BC119678 AAI19679 BC119679 AAI19680 BI828714 XM_005248849 XP_005248906 XM_011514296 XP_011512598 XM_011514297 XP_011512599 NM_138572 NP_612639 |
| Function | Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:14580349}. Cytoplasm {ECO:0000250}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}. |
| Top Pathways | Basal transcription factors |
TAF II p43 CRISPR/Cas9 KO Plasmid (h) - sc-414355 from Santa Cruz Biotechnology
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TAF II p43 HDR Plasmid (h) - sc-414355-HDR from Santa Cruz Biotechnology
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TAF II p43 Double Nickase Plasmid (h) - sc-414355-NIC from Santa Cruz Biotechnology
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TAF II p43 Double Nickase Plasmid (h2) - sc-414355-NIC-2 from Santa Cruz Biotechnology
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TAF II p43 CRISPR Activation Plasmid (h) - sc-414355-ACT from Santa Cruz Biotechnology
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TAF II p43 CRISPR Activation Plasmid (h2) - sc-414355-ACT-2 from Santa Cruz Biotechnology
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TAF II p43 Lentiviral Activation Particles (h) - sc-414355-LAC from Santa Cruz Biotechnology
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TAF II p43 Lentiviral Activation Particles (h2) - sc-414355-LAC-2 from Santa Cruz Biotechnology
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TAF II p43 siRNA (h) - sc-95445 from Santa Cruz Biotechnology
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TAF II p43 shRNA Plasmid (h) - sc-95445-SH from Santa Cruz Biotechnology
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TAF II p43 shRNA (h) Lentiviral Particles - sc-95445-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20980 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20980 from Sigma-Aldrich
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TAF8 siRNA (Human) - CRJ5008 from Cohesion Biosciences
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TAF8 - MBS8236004 from MyBioSource
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shRNA set against Human TAF8 (NM_138572.2) - SHH422812 from Creative biogene
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shRNA set against Human TBN(NM_138572.2) - SHL055225 from Creative biogene
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shRNA set against Human TAGAP(NM_138810.2) - SHL055242 from Creative biogene
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Human TAF8 siRNA - orb275509 from Biorbyt
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TAF8 shRNA Plasmid (Human) - CHJ5008 from Cohesion Biosciences
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TAF8 miRNA 3'UTR clone - MiUTR1H-10235 from Creative biogene
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