PKD2

Gene Symbol	PKD2
Entrez Gene	5311
Alt Symbol	APKD2, PC2, PKD4, Pc-2, TRPP2
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 2 (autosomal dominant)
Other Description	R48321|autosomal dominant polycystic kidney disease type II protein|polycystin-2|polycystwin|transient receptor potential cation channel, subfamily P, member 2
Swissprots	Q15764 Q13563 O60441 Q2M1Q3 Q2M1Q5
Accessions	AAC16004 AAG15529 AJP06023 AJP06024 EAX06011 Q13563 AF054992 AAC09351 AF113693 AK293461 BAG56956 AK294173 BAG57494 AK294589 BAH11820 AW600307 BC111454 AAI11455 BC112261 AAI12262 BC112263 AAI12264 BQ574566 U50928 AAC50520 U56813 AAC50933 XM_011532028 XP_011530330 XM_011532029 XP_011530331 XM_011532030 XP_011530332 XR_244632 NM_000297 NP_000288
Function	Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO:0000250}.
Subcellular Location	Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed:8650545}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Polycystin-2 (D-3) - sc-28331 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Polyclonal

Polycystin-2 (E-20) - sc-10377 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-2 (G-20) - sc-10376 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Polycystin-2 (H-280) - sc-25749 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Polycystin-2 (YCE2) - sc-47734 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Polyclonal

Anti-Polycystin 2 antibody - ab72274 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Polycystin 2 antibody - ab55600 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Polycystin 2 antibody - ab55947 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (C-Terminus) - LS-C46906 from LifeSpan Bioscience Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (C-Terminus) - LS-C152853 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (phospho-Ser200) - LS-C190129 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (C-Terminus) - LS-C209719 from LifeSpan Bioscience Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, AP) - LS-C266425 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, APC) - LS-C266426 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, FITC) - LS-C266427 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, Azide-free, HRP) - LS-C266428 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, Biotin) - LS-C266429 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903, PE) - LS-C266430 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa871-883) - LS-C108143 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (phospho-Ser812) - LS-C291179 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa873-903) - LS-C329976 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa196-245) - LS-C201302 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa874-903) - LS-C163746 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PRKD2 / PKD2 Antibody (Ala872) - LS-C176459 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PKD2 / Polycystin 2 Antibody (aa918-968) IHC-plus™ - LS-B11063 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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