PKD2

Gene Symbol	PKD2
Entrez Gene	5311
Alt Symbol	APKD2, PC2, PKD4, Pc-2, TRPP2
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 2 (autosomal dominant)
Other Description	R48321|autosomal dominant polycystic kidney disease type II protein|polycystin-2|polycystwin|transient receptor potential cation channel, subfamily P, member 2
Swissprots	Q15764 Q13563 O60441 Q2M1Q3 Q2M1Q5
Accessions	AAC16004 AAG15529 AJP06023 AJP06024 EAX06011 Q13563 AF054992 AAC09351 AF113693 AK293461 BAG56956 AK294173 BAG57494 AK294589 BAH11820 AW600307 BC111454 AAI11455 BC112261 AAI12262 BC112263 AAI12264 BQ574566 U50928 AAC50520 U56813 AAC50933 XM_011532028 XP_011530330 XM_011532029 XP_011530331 XM_011532030 XP_011530332 XR_244632 NM_000297 NP_000288
Function	Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO:0000250}.
Subcellular Location	Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed:8650545}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Protein Kinase D2 full length protein - ab172191 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Polycystin 2 protein fragment - ab114461 from Abcam Category Protein Source Wheat germ Species Human

PKD2-Antibody-C-term-Blocking-Peptide - BP14827b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Polycystin 2 blocking peptide - GTX88317-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

Polycystin 2 Peptide - AC21-1953-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PKD2 - H00005311-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PKD2 - H00005311-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PKD2 - P4195 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PKD2 Peptide - 42-125P from ProSci Category Peptide Species Human

Recombinant Human PKD2, GST-tagged, Active - PKD2-410H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human PKD2 - PKD2-30689TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Polycystic Kidney Disease 2 (Autosomal Dominant) - PKD2-660H from Creative Biomart Category Protein Source E.coli.

Recombinant Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) - RPE182Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Keratin 17 (KRT17) - RPB822Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Active PKD2 - 7711-5 from Biovision Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKD2, Recombinant Protein - MBS844556 from MyBioSource Category Protein Prices $345.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Polycystin 2/PKD2, Peptide - MBS425723 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

Polycystin 2 protein - orb86196 from Biorbyt Category Protein Prices $451.00 Sizes 500 µg

PKD2, Active - 7711 from Biovision Category Protein Prices $295.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells)

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