PKD2

Gene Symbol	PKD2
Entrez Gene	5311
Alt Symbol	APKD2, PC2, PKD4, Pc-2, TRPP2
Species	Human
Gene Type	protein-coding
Description	polycystic kidney disease 2 (autosomal dominant)
Other Description	R48321|autosomal dominant polycystic kidney disease type II protein|polycystin-2|polycystwin|transient receptor potential cation channel, subfamily P, member 2
Swissprots	Q15764 Q13563 O60441 Q2M1Q3 Q2M1Q5
Accessions	AAC16004 AAG15529 AJP06023 AJP06024 EAX06011 Q13563 AF054992 AAC09351 AF113693 AK293461 BAG56956 AK294173 BAG57494 AK294589 BAH11820 AW600307 BC111454 AAI11455 BC112261 AAI12262 BC112263 AAI12264 BQ574566 U50928 AAC50520 U56813 AAC50933 XM_011532028 XP_011530330 XM_011532029 XP_011530331 XM_011532030 XP_011530332 XR_244632 NM_000297 NP_000288
Function	Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO:0000250}.
Subcellular Location	Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed:8650545}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Procollagen II (PCII), Human, ELISA Kit - SEC017Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.107ng/mL Range 0.312-20ng/mL

Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2), Human, ELISA Kit - SEE182Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.101ng/mL Range 0.312-20ng/mL

PKD2, ELISA Kit - MBS2504226 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

PKD2, ELISA Kit - MBS2500473 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKD2, ELISA Kit - MBS2514823 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKD2, ELISA Kit - MBS2508684 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKD2, ELISA Kit - MBS2515092 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

PKD2, ELISA Kit - MBS2508703 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

PKD2, ELISA Kit - MBS2502568 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

PKD2, ELISA Kit - MBS2515446 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2) - SEE182Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.101ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Keratin 17 (KRT17) - SEB822Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.071ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Procollagen II (PCII) - SEC017Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Bovine PKD2 / Polycystin 2 ELISA Kit (Custom ELISA) - LS-F17578 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Mouse PKD2 / Polycystin 2 ELISA Kit (Custom ELISA) - LS-F17577 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Polycystin-2, ELISA Kit - MBS282949 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Polycystin-2 ELISA Kit - abx250993 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human PKD2 / Polycystin 2 ELISA Kit (Competitive EIA) - LS-F13398 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Human Polycystin-2 ELISA Kit - EKE55132 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.098 ng/ml Range 0.312-20 ng/mL

PKD2 ELISA Kit (Human) : 96 Wells (OKEH02411) - OKEH02411 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.098 ng/mL Range 0.312 - 20 ng/mL

Human PC2 ELISA Kit - E030924 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

Human Polycystin-2 ELISA Kit - EK3536 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.098ng/ml Range 0.312-20 ng/mL

Polycystin-2, ELISA Kit - MBS761096 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Polycystin-2, ELISA Kit - MBS288823 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Polycystin-2, ELISA Kit - MBS9427370 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.098ng/mL Range 0.312-20 ng/mL

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