PKD2

Gene Symbol PKD2
Entrez Gene 5311
Alt Symbol APKD2, PC2, PKD4, Pc-2, TRPP2
Species Human
Gene Type protein-coding
Description polycystic kidney disease 2 (autosomal dominant)
Other Description R48321|autosomal dominant polycystic kidney disease type II protein|polycystin-2|polycystwin|transient receptor potential cation channel, subfamily P, member 2
Swissprots Q15764 Q13563 O60441 Q2M1Q3 Q2M1Q5
Accessions AAC16004 AAG15529 AJP06023 AJP06024 EAX06011 Q13563 AF054992 AAC09351 AF113693 AK293461 BAG56956 AK294173 BAG57494 AK294589 BAH11820 AW600307 BC111454 AAI11455 BC112261 AAI12262 BC112263 AAI12264 BQ574566 U50928 AAC50520 U56813 AAC50933 XM_011532028 XP_011530330 XM_011532029 XP_011530331 XM_011532030 XP_011530332 XR_244632 NM_000297 NP_000288
Function Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO:0000250}.
Subcellular Location Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed:8650545}.

Polycystin-2 CRISPR/Cas9 KO Plasmid (h) - sc-400669 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 HDR Plasmid (h) - sc-400669-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 Double Nickase Plasmid (h) - sc-400669-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 Double Nickase Plasmid (h2) - sc-400669-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 CRISPR Activation Plasmid (h) - sc-400669-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 CRISPR Activation Plasmid (h2) - sc-400669-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 Lentiviral Activation Particles (h) - sc-400669-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 Lentiviral Activation Particles (h2) - sc-400669-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Polycystin-2 siRNA (h) - sc-40863 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Polycystin-2 shRNA Plasmid (h) - sc-40863-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Polycystin-2 shRNA (h) Lentiviral Particles - sc-40863-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU029001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1675 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1675 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PKD2 siRNA (Human) - CRH3553 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PKD2 (NM_000297.3) - SHH376388 from Creative biogene

Category siRNA
Species Reactivities Human

PKD2 shRNA Plasmid (Human) - CHH3553 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PKD2 miRNA 3'UTR clone - MiUTR4H-TG06726 from Creative biogene

Species Reactivities Human
Search more