Gene Symbol | PKD2 |
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Entrez Gene | 5311 |
Alt Symbol | APKD2, PC2, PKD4, Pc-2, TRPP2 |
Species | Human |
Gene Type | protein-coding |
Description | polycystic kidney disease 2 (autosomal dominant) |
Other Description | R48321|autosomal dominant polycystic kidney disease type II protein|polycystin-2|polycystwin|transient receptor potential cation channel, subfamily P, member 2 |
Swissprots | Q15764 Q13563 O60441 Q2M1Q3 Q2M1Q5 |
Accessions | AAC16004 AAG15529 AJP06023 AJP06024 EAX06011 Q13563 AF054992 AAC09351 AF113693 AK293461 BAG56956 AK294173 BAG57494 AK294589 BAH11820 AW600307 BC111454 AAI11455 BC112261 AAI12262 BC112263 AAI12264 BQ574566 U50928 AAC50520 U56813 AAC50933 XM_011532028 XP_011530330 XM_011532029 XP_011530331 XM_011532030 XP_011530332 XR_244632 NM_000297 NP_000288 |
Function | Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. |
Tissue Specificity | Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. {ECO:0000269|PubMed:8650545}. |
Polycystin-2 CRISPR/Cas9 KO Plasmid (h) - sc-400669 from Santa Cruz Biotechnology
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Polycystin-2 HDR Plasmid (h) - sc-400669-HDR from Santa Cruz Biotechnology
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Polycystin-2 Double Nickase Plasmid (h) - sc-400669-NIC from Santa Cruz Biotechnology
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Polycystin-2 Double Nickase Plasmid (h2) - sc-400669-NIC-2 from Santa Cruz Biotechnology
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Polycystin-2 CRISPR Activation Plasmid (h) - sc-400669-ACT from Santa Cruz Biotechnology
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Polycystin-2 CRISPR Activation Plasmid (h2) - sc-400669-ACT-2 from Santa Cruz Biotechnology
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Polycystin-2 Lentiviral Activation Particles (h) - sc-400669-LAC from Santa Cruz Biotechnology
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Polycystin-2 Lentiviral Activation Particles (h2) - sc-400669-LAC-2 from Santa Cruz Biotechnology
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Polycystin-2 siRNA (h) - sc-40863 from Santa Cruz Biotechnology
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Polycystin-2 shRNA Plasmid (h) - sc-40863-SH from Santa Cruz Biotechnology
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Polycystin-2 shRNA (h) Lentiviral Particles - sc-40863-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1675 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1675 from Sigma-Aldrich
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PKD2 siRNA (Human) - CRH3553 from Cohesion Biosciences
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shRNA set against Human PKD2 (NM_000297.3) - SHH376388 from Creative biogene
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PKD2 shRNA Plasmid (Human) - CHH3553 from Cohesion Biosciences
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PKD2 miRNA 3'UTR clone - MiUTR4H-TG06726 from Creative biogene
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