| Gene Symbol | Cdkn1a |
|---|---|
| Entrez Gene | 12575 |
| Alt Symbol | CAP20, CDKI, CIP1, Cdkn1, P21, SDI1, Waf1, mda6, p21Cip1, p21WAF |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 1A (P21) |
| Other Description | CDK-interacting protein 1|cyclin-dependent kinase inhibitor 1|cyclin-dependent kinase inhibitor 1A variant 1|cyclin-dependent kinase inhibitor 1A variant 2|melanoma differentiation-associated protein|p21<WAF1/CIP1> |
| Swissprots | P39689 |
| Accessions | AAL57889 AAT73700 AGH67764 AGH67765 EDL22607 EDL22608 EDL22609 P39689 AB017817 BAA82341 AB017818 BAA82342 AK007630 BAB25148 AK089093 BAC40747 AK139306 BAE23949 AK149910 BAE29160 AK170467 BAE41815 AK194916 AK202927 AK210703 BC002043 AAH02043 BY206886 CT010218 CAJ18426 U09507 AAB60456 U24173 AAC52220 NM_001111099 NP_001104569 NM_007669 NP_031695 |
| Function | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20154723}. |
| Top Pathways | HTLV-I infection, MicroRNAs in cancer, Epstein-Barr virus infection, Oxytocin signaling pathway, Proteoglycans in cancer |