| Gene Symbol | Cdkn1a |
|---|---|
| Entrez Gene | 12575 |
| Alt Symbol | CAP20, CDKI, CIP1, Cdkn1, P21, SDI1, Waf1, mda6, p21Cip1, p21WAF |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 1A (P21) |
| Other Description | CDK-interacting protein 1|cyclin-dependent kinase inhibitor 1|cyclin-dependent kinase inhibitor 1A variant 1|cyclin-dependent kinase inhibitor 1A variant 2|melanoma differentiation-associated protein|p21<WAF1/CIP1> |
| Swissprots | P39689 |
| Accessions | AAL57889 AAT73700 AGH67764 AGH67765 EDL22607 EDL22608 EDL22609 P39689 AB017817 BAA82341 AB017818 BAA82342 AK007630 BAB25148 AK089093 BAC40747 AK139306 BAE23949 AK149910 BAE29160 AK170467 BAE41815 AK194916 AK202927 AK210703 BC002043 AAH02043 BY206886 CT010218 CAJ18426 U09507 AAB60456 U24173 AAC52220 NM_001111099 NP_001104569 NM_007669 NP_031695 |
| Function | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20154723}. |
| Top Pathways | HTLV-I infection, MicroRNAs in cancer, Epstein-Barr virus infection, Oxytocin signaling pathway, Proteoglycans in cancer |
p21 CRISPR/Cas9 KO Plasmid (m) - sc-419607 from Santa Cruz Biotechnology
|
||||||||
p21 HDR Plasmid (m) - sc-419607-HDR from Santa Cruz Biotechnology
|
||||||||
p21 Double Nickase Plasmid (m) - sc-419607-NIC from Santa Cruz Biotechnology
|
||||||||
p21 Double Nickase Plasmid (m2) - sc-419607-NIC-2 from Santa Cruz Biotechnology
|
||||||||
p21 CRISPR Activation Plasmid (m) - sc-419607-ACT from Santa Cruz Biotechnology
|
||||||||
p21 CRISPR Activation Plasmid (m2) - sc-419607-ACT-2 from Santa Cruz Biotechnology
|
||||||||
p21 Lentiviral Activation Particles (m) - sc-419607-LAC from Santa Cruz Biotechnology
|
||||||||
p21 Lentiviral Activation Particles (m2) - sc-419607-LAC-2 from Santa Cruz Biotechnology
|
||||||||
p21 siRNA (m) - sc-29428 from Santa Cruz Biotechnology
|
||||||||
p21 shRNA Plasmid (m) - sc-29428-SH from Santa Cruz Biotechnology
|
||||||||
p21 shRNA (m) Lentiviral Particles - sc-29428-V from Santa Cruz Biotechnology
|
||||||||
p21 siRNA (m2) - sc-44271 from Santa Cruz Biotechnology
|
||||||||
p21 shRNA Plasmid (m2) - sc-44271-SH from Santa Cruz Biotechnology
|
||||||||
p21 shRNA (m2) Lentiviral Particles - sc-44271-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU013421 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN28504 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28504 from Sigma-Aldrich
|
||||||||
CDKN1A siRNA (Mouse) - CRM0646 from Cohesion Biosciences
|
||||||||
CDKN1A - MBS8240688 from MyBioSource
|
||||||||
shRNA set against Mouse CDKN1A (NM_007669.4) - SHH260813 from Creative biogene
|
||||||||
shRNA set against Mouse Cdkn1a(NM_007669.4) - SHG165169 from Creative biogene
|
||||||||
Mouse CDKN1A siRNA - orb280122 from Biorbyt
|
||||||||
CDKN1A shRNA Plasmid (Mouse) - CHM0646 from Cohesion Biosciences
|
||||||||
CDKN1A miRNA 3'UTR clone - MiUTR1M-02878 from Creative biogene
|