| Gene Symbol |
PSIP1
|
| Entrez Gene |
11168
|
| Alt Symbol |
DFS70, LEDGF, PAIP, PSIP2, p52, p75
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PC4 and SFRS1 interacting protein 1
|
| Other Description |
CLL-associated antigen KW-7|DFS 70|PC4 and SFRS1-interacting protein|dense fine speckles 70 kDa protein|lens epithelium-derived growth factor|transcriptional coactivator p52/p75|transcriptional coactivator p75/p52
|
| Swissprots |
Q9NZI3 O95368 Q9UER6 O75475 Q6P391 D3DRI9 Q86YB9 O00256
|
| Accessions |
AAF25870 AAF25871 CCQ43795 EAW58675 EAW58676 EAW58677 EAW58678 EAW58679 O75475 AF063020 AAC25167 AF098482 AAC97945 AF098483 AAC97946 AF432220 AAL99926 AK096405 BC013160 BC022971 AAH22971 BC033817 AAH33817 BC040032 BC044568 AAH44568 BC064135 AAH64135 BQ186453 BX649155 DA117094 U94319 AAB52589 XM_005251358 XP_005251415 XM_011517697 XP_011515999 XM_011517698 XP_011516000 XM_011517699 XP_011516001 XM_011517700 XP_011516002 NM_001128217 NP_001121689 NM_021144 NP_066967 NM_033222 NP_150091
|
| Function |
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9822615}.
|