PSIP1

Gene Symbol	PSIP1
Entrez Gene	11168
Alt Symbol	DFS70, LEDGF, PAIP, PSIP2, p52, p75
Species	Human
Gene Type	protein-coding
Description	PC4 and SFRS1 interacting protein 1
Other Description	CLL-associated antigen KW-7\|DFS 70\|PC4 and SFRS1-interacting protein\|dense fine speckles 70 kDa protein\|lens epithelium-derived growth factor\|transcriptional coactivator p52/p75\|transcriptional coactivator p75/p52
Swissprots	Q9NZI3 O95368 Q9UER6 O75475 Q6P391 D3DRI9 Q86YB9 O00256
Accessions	AAF25870 AAF25871 CCQ43795 EAW58675 EAW58676 EAW58677 EAW58678 EAW58679 O75475 AF063020 AAC25167 AF098482 AAC97945 AF098483 AAC97946 AF432220 AAL99926 AK096405 BC013160 BC022971 AAH22971 BC033817 AAH33817 BC040032 BC044568 AAH44568 BC064135 AAH64135 BQ186453 BX649155 DA117094 U94319 AAB52589 XM_005251358 XP_005251415 XM_011517697 XP_011515999 XM_011517698 XP_011516000 XM_011517699 XP_011516001 XM_011517700 XP_011516002 NM_001128217 NP_001121689 NM_021144 NP_066967 NM_033222 NP_150091
Function	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269\|PubMed:15642333}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:15642333, ECO:0000269\|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
Tissue Specificity	Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269\|PubMed:15642333, ECO:0000269\|PubMed:9822615}.

LEDGF (C57G11) Rabbit mAb - 2088 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	C57G11

Western blot analysis of exctracts from various cell types using LEDGF (C57G11) Rabbit mAb.

PSIP1 (C-16) - sc-33371 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PSIP1 (C-16): sc-33371. Western blot analysis of PSIP1 expression in K-562 whole cell lysate.

PSIP1 (3F7) - sc-101087 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

LEDGF/p75p52 (3F7): sc-101087. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing nuclear localization.

PSIP1 (26) - sc-136227 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

Anti-PSIP1 antibody - ab70641 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma (left) and mouse renal cell carcinoma (right) tissues labelling PSIP1 with ab70641 at 1/1000 (1µg/ml). Detection: DAB.

Anti-PSIP1 antibody - ab56841 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

PSIP1 antibody (ab56841) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human testis.

Anti-PSIP1 antibody - ab28431 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 antibody [6E4] - ab110023 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6E4

All lanes : Anti-PSIP1 antibody [6E4] (ab110023) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : Jurkat cell lysateLane 3 : K562 cell lysateLane 4 : Cos7 cell lysateLane 5 : PC-12 cell lysateLane 6 : Hela cell lysateLane 7 : NIH3T3 cell lysate

Anti-PSIP1 antibody [EPR11890] - ab177159 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11890

All lanes : Anti-PSIP1 antibody [EPR11890] (ab177159) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PSIP1 / LEDGF Antibody (aa311-469, Biotin) - LS-C297038 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa311-469, Biotin) - LS-C301098 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa311-469, FITC) - LS-C304015 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF / p75 Antibody (aa1-51, Azide-free) - LS-C330593 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-PSIP1 / LEDGF Antibody (aa311-469, FITC) - LS-C304132 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa1-530) - LS-C149990 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

LEDGF in HeLa Human Cell Line. LEDGF was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human LEDGF Antigen Affinity-purified Polyclonal Antibody at 10 ug/ml for 3 hours at room temperature. Cells were stained using NorthernLights 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei.

Anti-PSIP1 / LEDGF Antibody (C-Terminus) - LS-C109946 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

PSIP1 antibody LS-C109946 Western blot of 721_B cell lysate.

Anti-PSIP1 / LEDGF Antibody (aa311-469) - LS-C295117 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant PSIP1 / LEDGF / p75.

Anti-PSIP1 / LEDGF Antibody (aa311-469) - LS-C295116 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa225-275) - LS-C287695 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human and Mouse by Immunohistochemistry. Sample: FFPE sections of human lung carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti- used at a dilution of 1:1000 (1 Detection: DAB.

Anti-PSIP1 / LEDGF Antibody (clone 3H1) - LS-C133679 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3H1

Immunoperoxidase of monoclonal antibody to PSIP1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]

Anti-PSIP1 / LEDGF Antibody (clone 6E4) - LS-C169302 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6E4

IHC of paraffin-embedded lung cancer tissues (left) and brain tissues (right) using PSIP1 mouse monoclonal antibody with DAB staining.

Anti-PSIP1 / LEDGF Antibody (aa225-275) - LS-C71581 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa225-275) - LS-C71582 from LifeSpan Bioscience

Prices	$575.00
Sizes	20 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa311-360) - LS-C29936 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSIP1 / LEDGF Antibody (aa311-360) - LS-C31241 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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