HTR6

Gene Symbol HTR6
Entrez Gene 3362
Alt Symbol 5-HT6, 5-HT6R
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Other Description 5-hydroxytryptamine receptor 6|serotonin receptor 6
Swissprots P50406 Q5TGZ1 Q13640
Accessions EAW94896 P50406 AB209129 BAD92366 AF007141 AY429105 AAR07900 BC074995 AAH74995 BC074996 AAH74996 L41147 AAA92622 Z49119 CAA88929 NM_000871 NP_000862
Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in several human brain regions, most prominently in the caudate nucleus.
Top Pathways Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

SR-6 (A-20) - sc-26668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-6 (A-20): sc-26668. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing membrane and cytoplasmic staining of glandular cells.

SR-6 (H-143) - sc-28962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SR-6 (H-143): sc-28962. Western blot analysis of SR-6 expression in c4 whole cell lysate.

SR-6 (P-20) - sc-26669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-6 (R-15) - sc-33351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-5HT6 Receptor antibody - ab101911 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-HTR6 / 5-HT6 Receptor Antibody (aa1-50) - LS-C291041 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human 5-HT6 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using RIPA buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-5-HT6 antibody used for IP at 6 ug per reaction. 5-HT6 was also immunoprecipitated by rabbit anti-5-HT6 antibody BL16176. For blotting immunoprecipitated 5-HT6, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-HTR6 / 5-HT6 Receptor Antibody (aa196-245) - LS-C200063 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from COLO205 cells using 5-HT-6 antibody.

Anti-HTR6 / 5-HT6 Receptor Antibody (C-Terminus) IHC-plus™ - LS-A652 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Brain, Cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-HTR6 / 5-HT6 Receptor Antibody (C-Terminus) IHC-plus™ - LS-A650 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

CA19-9 Antibody (121SLE) - NBP2-15182 from Novus Biologicals

Prices $299.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 121SLE
Immunohistochemistry-Paraffin: CA19-9 Antibody (121SLE) [NBP2-15182] - Formalin-paraffin colon carcinoma stained with CA19-9 Ab (121SLE). Note staining of luminal surface and cytoplasm of tumor cells.

5-HT6 Antibody - NBP2-32079 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: 5-HT6 Antibody [NBP2-32079] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using RIPA buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-5-HT6 antibody NBP2-32079 used for IP at 6 ug per reaction. 5-HT6 was also immunoprecipitated by rabbit anti-5-HT6 antibody BL16176. For blotting immunoprecipitated 5-HT6, NBP2-32079 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-HTR6/5-HT36 antibody produced in rabbit - SAB2900617 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HTR6/5-HT36 (Cytoplasmic Domain), antibody produced in rabbit: <B>Cat. No. SAB2900617</B>: Anti-HTR6/5-HT6 antibody IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR6/5-HT36 antibody produced in rabbit - SAB2900618 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HTR6/5-HT36 (C-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900618</B>: Anti-HTR6/5-HT6 antibody IHC staining of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HTR6 Antibody (OAAF02806) - OAAF02806 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

5-HT-6 Antibody (OAAF06030) - OAAF06030 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HTR6 Antibody (OALA01034) - OALA01034 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

HTR6 Antibody (OALA01035) - OALA01035 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

5-HT-6 Antibody - abx013890 from Abbexa

Host Rabbit
Clonality Polyclonal

Serotonin receptor 6 (HTR6) (C-term) antibody - AP10420PU-N from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Serotonin receptor 6 (HTR6) (C-term) antibody - SP4049P from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of Brain (Neuron) using anti- HTR6 antibody SP4049P

Anti-SR-6 antibody - STJ95773 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

5-HT-6 Polyclonal Antibody - PA006206-R12-2422 from Syd Labs

Prices $150.00, $250.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal
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