HTR6

Gene Symbol	HTR6
Entrez Gene	3362
Alt Symbol	5-HT6, 5-HT6R
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Other Description	5-hydroxytryptamine receptor 6|serotonin receptor 6
Swissprots	P50406 Q5TGZ1 Q13640
Accessions	EAW94896 P50406 AB209129 BAD92366 AF007141 AY429105 AAR07900 BC074995 AAH74995 BC074996 AAH74996 L41147 AAA92622 Z49119 CAA88929 NM_000871 NP_000862
Function	This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in several human brain regions, most prominently in the caudate nucleus.
Top Pathways	Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTR6 / 5-HT6 Receptor Blocking Peptide - LS-E29133 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR6 / 5-HT6 Receptor Antibody Blocking Peptide - LS-E29134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR6 fusion protein - ag15396 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HTR6 fusion protein - ag14742 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT 6 Serotonin Receptor - HTS111M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein - MBS960239 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HTR6 Peptide, Human - M34GP07352H from Creative Peptides Category Peptide Source Synthetic. Species Human

5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein - MBS7017315 from MyBioSource Category Protein Prices $1,245.00, $2,230.00, $3,435.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein - MBS7017317 from MyBioSource Category Protein Prices $1,245.00, $2,230.00, $3,435.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Chimpanzee

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