| Gene Symbol |
HTR6
|
| Entrez Gene |
3362
|
| Alt Symbol |
5-HT6, 5-HT6R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
|
| Other Description |
5-hydroxytryptamine receptor 6|serotonin receptor 6
|
| Swissprots |
P50406 Q5TGZ1 Q13640
|
| Accessions |
EAW94896 P50406 AB209129 BAD92366 AF007141 AY429105 AAR07900 BC074995 AAH74995 BC074996 AAH74996 L41147 AAA92622 Z49119 CAA88929 NM_000871 NP_000862
|
| Function |
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in several human brain regions, most prominently in the caudate nucleus.
|
| Top Pathways |
Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|