Gene Symbol | MAS1 |
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Entrez Gene | 4142 |
Alt Symbol | MAS, MGRA |
Species | Human |
Gene Type | protein-coding |
Description | MAS1 proto-oncogene, G protein-coupled receptor |
Other Description | MAS1 oncogene|Mas-related G protein-coupled receptor A|proto-oncogene Mas |
Swissprots | E1P5B3 Q6FG47 Q2TBC9 P04201 |
Accessions | CDG86183 EAW47609 EAW47610 EAW47611 P04201 BC069142 AAH69142 BC069581 AAH69581 BC110454 AAI10455 CR542261 CAG47057 HQ448438 ADQ32918 M13150 AAA36199 NM_002377 NP_002368 |
Function | Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000269|PubMed:16611642}. |
Top Pathways | Renin-angiotensin system, Neuroactive ligand-receptor interaction |
MAS1 (G-1) - sc-390453 from Santa Cruz Biotechnology
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MAS1 (C-13) - sc-54846 from Santa Cruz Biotechnology
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MAS1 (H-117) - sc-135063 from Santa Cruz Biotechnology
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MAS1 (N-15) - sc-54682 from Santa Cruz Biotechnology
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Anti-MAS1 antibody - ab66030 from Abcam
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Anti-MAS1 antibody - ab197992 from Abcam
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Anti-MAS1 antibody - ab123326 from Abcam
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Anti-MAS1 antibody - Extracellular domain - ab140884 from Abcam
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Anti-MAS1 antibody - N-terminal - ab182363 from Abcam
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Anti-MAS1 / MAS Antibody - LS-C180175 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa144-193) - LS-C81614 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa285-314) - LS-C164041 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (Biotin) - LS-C180900 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY650) - LS-C180901 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY488) - LS-C180902 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (HRP) - LS-C180903 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY550) - LS-C180904 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (Biotin) - LS-C182020 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY650) - LS-C182021 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY550) - LS-C182023 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (DY488) - LS-C182022 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa285-314, AP) - LS-C215738 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa285-314, APC) - LS-C215739 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa285-314, FITC) - LS-C215740 from LifeSpan Bioscience
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Anti-MAS1 / MAS Antibody (aa284-314) - LS-C322866 from LifeSpan Bioscience
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