Gene Symbol | MAS1 |
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Entrez Gene | 4142 |
Alt Symbol | MAS, MGRA |
Species | Human |
Gene Type | protein-coding |
Description | MAS1 proto-oncogene, G protein-coupled receptor |
Other Description | MAS1 oncogene|Mas-related G protein-coupled receptor A|proto-oncogene Mas |
Swissprots | E1P5B3 Q6FG47 Q2TBC9 P04201 |
Accessions | CDG86183 EAW47609 EAW47610 EAW47611 P04201 BC069142 AAH69142 BC069581 AAH69581 BC110454 AAI10455 CR542261 CAG47057 HQ448438 ADQ32918 M13150 AAA36199 NM_002377 NP_002368 |
Function | Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000269|PubMed:16611642}. |
Top Pathways | Renin-angiotensin system, Neuroactive ligand-receptor interaction |
Human MAS1 full length protein - ab158861 from Abcam
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MAS1 peptide - ab150298 from Abcam
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MAS1 / MAS Antibody Blocking Peptide - LS-E3091 from LifeSpan Bioscience
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MAS1 / MAS Antibody Blocking Peptide - LS-E18428 from LifeSpan Bioscience
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MAS1 / MAS Antibody Blocking Peptide - LS-E28307 from LifeSpan Bioscience
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MAS1 / MAS Antibody Blocking Peptide - LS-E28306 from LifeSpan Bioscience
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MAS1 / MAS Antibody Blocking Peptide - LS-E28309 from LifeSpan Bioscience
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Mas Recombinant Protein - H00004142-P01 from Novus Biologicals
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MAS1-Antibody-C-term-Blocking-Peptide - BP14230b from Abgent, a WuXi AppTec company
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MAS1 Blocking Peptide - 33R-8095 from Fitzgerald
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MAS1 Blocking Peptide - 33R-9598 from Fitzgerald
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MAS proto-oncogene - H00004142-G01 from Acris Antibodies
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MAS proto-oncogene - H00004142-P01 from Acris Antibodies
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Recombinant Human Mas Protein - H00004142-G01 from Novus Biologicals
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MAS1 Protein - abx163098 from Abbexa
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MAS1 / MAS Blocking Peptide - LS-E39739 from LifeSpan Bioscience
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Mas Recombinant Protein Antigen - NBP1-86085PEP from Novus Biologicals
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MAS1 Peptide, Human - M34GP09244H from Creative Peptides
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Recombinant Human Proto-oncogene Mas(MAS1), partial - CSB-YP013505HU1 from Cusabio
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Proto-oncogene Mas (MAS1), Recombinant Protein - MBS958478 from MyBioSource
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Proto-oncogene Mas (MAS1), Recombinant Protein - MBS7019841 from MyBioSource
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Proto-oncogene Mas (MAS1), Recombinant Protein - MBS950640 from MyBioSource
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