Gene Symbol | MAS1 |
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Entrez Gene | 4142 |
Alt Symbol | MAS, MGRA |
Species | Human |
Gene Type | protein-coding |
Description | MAS1 proto-oncogene, G protein-coupled receptor |
Other Description | MAS1 oncogene|Mas-related G protein-coupled receptor A|proto-oncogene Mas |
Swissprots | E1P5B3 Q6FG47 Q2TBC9 P04201 |
Accessions | CDG86183 EAW47609 EAW47610 EAW47611 P04201 BC069142 AAH69142 BC069581 AAH69581 BC110454 AAI10455 CR542261 CAG47057 HQ448438 ADQ32918 M13150 AAA36199 NM_002377 NP_002368 |
Function | Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000269|PubMed:16611642}. |
Top Pathways | Renin-angiotensin system, Neuroactive ligand-receptor interaction |
MAS1 CRISPR/Cas9 KO Plasmid (h) - sc-401674 from Santa Cruz Biotechnology
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MAS1 HDR Plasmid (h) - sc-401674-HDR from Santa Cruz Biotechnology
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MAS1 Double Nickase Plasmid (h) - sc-401674-NIC from Santa Cruz Biotechnology
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MAS1 Double Nickase Plasmid (h2) - sc-401674-NIC-2 from Santa Cruz Biotechnology
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MAS1 CRISPR Activation Plasmid (h) - sc-401674-ACT from Santa Cruz Biotechnology
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MAS1 CRISPR Activation Plasmid (h2) - sc-401674-ACT-2 from Santa Cruz Biotechnology
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MAS1 Lentiviral Activation Particles (h) - sc-401674-LAC from Santa Cruz Biotechnology
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MAS1 Lentiviral Activation Particles (h2) - sc-401674-LAC-2 from Santa Cruz Biotechnology
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MAS1 siRNA (h) - sc-62600 from Santa Cruz Biotechnology
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MAS1 shRNA Plasmid (h) - sc-62600-SH from Santa Cruz Biotechnology
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MAS1 shRNA (h) Lentiviral Particles - sc-62600-V from Santa Cruz Biotechnology
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Mas RNAi - H00004142-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN13051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13051 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00429 from Sigma-Aldrich
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MAS1 siRNA (Human) - CRH2815 from Cohesion Biosciences
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shRNA set against Human MAS1 (NM_002377.2) - SHH338463 from Creative biogene
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shRNA set against Human MAS1(NM_002377.2) - SHH177995 from Creative biogene
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MAS1 shRNA Plasmid (Human) - CHH2815 from Cohesion Biosciences
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MAS1 miRNA 3'UTR clone - MiUTR1H-06114 from Creative biogene
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