| Gene Symbol |
MAS1
|
| Entrez Gene |
4142
|
| Alt Symbol |
MAS, MGRA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAS1 proto-oncogene, G protein-coupled receptor
|
| Other Description |
MAS1 oncogene|Mas-related G protein-coupled receptor A|proto-oncogene Mas
|
| Swissprots |
E1P5B3 Q6FG47 Q2TBC9 P04201
|
| Accessions |
CDG86183 EAW47609 EAW47610 EAW47611 P04201 BC069142 AAH69142 BC069581 AAH69581 BC110454 AAI10455 CR542261 CAG47057 HQ448438 ADQ32918 M13150 AAA36199 NM_002377 NP_002368
|
| Function |
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000269|PubMed:16611642}.
|
| Top Pathways |
Renin-angiotensin system, Neuroactive ligand-receptor interaction
|