| Gene Symbol |
SENP2
|
| Entrez Gene |
59343
|
| Alt Symbol |
AXAM2, SMT3IP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUMO1/sentrin/SMT3 specific peptidase 2
|
| Other Description |
SMT3-specific isopeptidase 2|SUMO1/sentrin/SMT3 specific protease 2|sentrin-specific protease 2|sentrin/SUMO-specific protease SENP2
|
| Swissprots |
Q96SR2 Q8IW97 Q9HC62 B4DQ42 Q9P2L5
|
| Accessions |
EAW78214 EAW78215 EAW78216 EAW78217 Q9HC62 AF151697 AAG15309 AK027599 BAB55222 AK074357 AK296744 BAG59328 AK296772 BAG59351 AK298628 BAG60804 AK304402 BAG65236 AL834380 CAD39043 BC018020 BC040609 AAH40609 XM_005247690 XP_005247747 XM_005247691 XP_005247748 NM_021627 NP_067640
|
| Function |
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. {ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:21965678}.
|
| Subcellular Location |
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
|
| Top Pathways |
Wnt signaling pathway, RNA transport
|