SENP3

Gene Symbol SENP3
Entrez Gene 26168
Alt Symbol SMT3IP1, SSP3, Ulp1
Species Human
Gene Type protein-coding
Description SUMO1/sentrin/SMT3 specific peptidase 3
Other Description SUMO-1-specific protease 3|sentrin-specific protease 3|sentrin/SUMO-specific protease 3
Swissprots Q96PS4 Q66K15 Q9H4L4 Q9Y3W9 Q86VS7
Accessions EAW90170 EAW90171 EAW90172 Q9H4L4 AF199459 AAL25652 AK000923 AL050283 CAB43384 AL557688 AL834294 CAD38967 AM392699 CAL37577 AM392708 CAL37586 AY008763 AAG33252 BC048306 AAH48306 BC080658 AAH80658 BF514106 BQ424754 BQ956948 CX165088 NM_015670 NP_056485
Function Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859}
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.

SENP3 (D20A10) XP ® Rabbit mAb - 5591 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D20A10
Western blot analysis of extracts from various cell lines using SENP3 (D20A10) XP ® Rabbit mAb.

SENP3 (C-13) - sc-46639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SENP3 (C-13): sc-46639. Western blot analysis of SENP3 expression in HeLa nuclear extract.

SENP3 (E-7) - sc-137219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SENP3 (E-7): sc-137219. Western blot analysis of SENP3 expression in non-transfected: sc-117752 (A) and human SENP3 transfected: sc-111446 (B) 293T whole cell lysates.

SENP3 (G-3) - sc-133149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SENP3 (G-3): sc-133149. Western blot analysis of SENP3 expression in non-transfected: sc-117752 (A) and human SENP3 transfected: sc-111446 (B) 293T whole cell lysates.

SENP3 (H-195) - sc-67076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SENP3 (H-195): sc-67076. Western blot analysis of SENP3 expression in Y79 nuclear extract.

SENP3 (S-13) - sc-46641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SENP3 (S-13): sc-46641. Western blot analysis of SENP3 expression in PC-3 nuclear extract.

SENP3 (T-18) - sc-46642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SENP3 (T-18): sc-46642. Western blot analysis of SENP3 expression in HeLa nuclear extract.

SENP3 (P-18) - sc-46640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SENP3 (P-18): sc-46640. Western blot analysis of SENP3 expression in HeLa nuclear extract (A) and MCF7 (B), Jurkat (C), Y79 (D) and U-698-M (E) whole cell lysates.

Anti-SENP3 antibody - ab58419 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue with ab58419 at 1/50 dilution, in the absence or presence of the immunizing peptide peptide.

Anti-SENP3 antibody [EP4360] - ab124790 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4360
All lanes : Anti-SENP3 antibody [EP4360] (ab124790) at 1/1000 dilutionLane 1 : MCF-7 cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-SENP3 antibody - Aminoterminal end - ab71677 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SENP3 antibody - Aminoterminal end (ab71677) at 1/100 dilution + Saos-2 cell lysate at 12.5 µg

Anti-SENP3 Antibody (aa1-17) - LS-C148191 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SENP3 in 15 ugs of NIH3T3 cell lysate using LS-C148191 at 1 ug/ml.

Anti-SENP3 Antibody (aa1-30) - LS-C98784 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SENP3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SENP3 Antibody (Tyr24) - LS-C176347 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of SENP3 (Y24) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-SENP3 Antibody (aa299-315) - LS-C10087 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (aa36-85) - LS-C111635 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SENP3 antibody LS-C111635 Western blot of 721_B cell lysate.

Anti-SENP3 Antibody (aa10-59) - LS-C118614 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using SENP3 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-SENP3 Antibody (N-Terminus, AP) - LS-C282561 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (N-Terminus, APC) - LS-C282563 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (N-Terminus, Biotin) - LS-C282564 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (N-Terminus, FITC) - LS-C282565 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (C-Terminus, clone EP4360) - LS-C138301 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4360
Western blot analysis on (A) MCF-7, (B) Jurkat, and (C) HeLa cell lysates using anti-SENP3 antibody.

Anti-SENP3 Antibody (N-Terminus, Azide-free, HRP) - LS-C282566 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (N-Terminus, PE) - LS-C282567 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SENP3 Antibody (aa1-50) - LS-C289837 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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