SENP3

Gene Symbol SENP3
Entrez Gene 26168
Alt Symbol SMT3IP1, SSP3, Ulp1
Species Human
Gene Type protein-coding
Description SUMO1/sentrin/SMT3 specific peptidase 3
Other Description SUMO-1-specific protease 3|sentrin-specific protease 3|sentrin/SUMO-specific protease 3
Swissprots Q96PS4 Q66K15 Q9H4L4 Q9Y3W9 Q86VS7
Accessions EAW90170 EAW90171 EAW90172 Q9H4L4 AF199459 AAL25652 AK000923 AL050283 CAB43384 AL557688 AL834294 CAD38967 AM392699 CAL37577 AM392708 CAL37586 AY008763 AAG33252 BC048306 AAH48306 BC080658 AAH80658 BF514106 BQ424754 BQ956948 CX165088 NM_015670 NP_056485
Function Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859}
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.

SENP3 CRISPR/Cas9 KO Plasmid (h) - sc-403747 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 HDR Plasmid (h) - sc-403747-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 Double Nickase Plasmid (h) - sc-403747-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 Double Nickase Plasmid (h2) - sc-403747-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 CRISPR Activation Plasmid (h) - sc-403747-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 CRISPR Activation Plasmid (h2) - sc-403747-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 Lentiviral Activation Particles (h) - sc-403747-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 Lentiviral Activation Particles (h2) - sc-403747-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SENP3 siRNA (h) - sc-44451 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP3 shRNA Plasmid (h) - sc-44451-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP3 shRNA (h) Lentiviral Particles - sc-44451-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SENP3 RNAi - H00026168-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU043671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19087 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19087 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SENP3 siRNA (Human) - CRH8747 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SENP3 - MBS8214187 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SENP3 (NM_015670.5) - SHH404480 from Creative biogene

Category siRNA
Species Reactivities Human

Human SENP3 siRNA - orb269249 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SENP3 shRNA Plasmid (Human) - CHH8747 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SENP3 miRNA 3'UTR clone - MiUTR3H-12642 from Creative biogene

Species Reactivities Human
Search more