SENP3

Gene Symbol	SENP3
Entrez Gene	26168
Alt Symbol	SMT3IP1, SSP3, Ulp1
Species	Human
Gene Type	protein-coding
Description	SUMO1/sentrin/SMT3 specific peptidase 3
Other Description	SUMO-1-specific protease 3|sentrin-specific protease 3|sentrin/SUMO-specific protease 3
Swissprots	Q96PS4 Q66K15 Q9H4L4 Q9Y3W9 Q86VS7
Accessions	EAW90170 EAW90171 EAW90172 Q9H4L4 AF199459 AAL25652 AK000923 AL050283 CAB43384 AL557688 AL834294 CAD38967 AM392699 CAL37577 AM392708 CAL37586 AY008763 AAG33252 BC048306 AAH48306 BC080658 AAH80658 BF514106 BQ424754 BQ956948 CX165088 NM_015670 NP_056485
Function	Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859}
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SENP3 protein fragment - ab161918 from Abcam Category Protein Source Wheat germ Species Human

SENP3 Antibody Blocking Peptide - LS-E1603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP3 Antibody Blocking Peptide - LS-E19982 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SENP3 Protein - H00026168-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

SENP3 Peptide - P0299 from Novus Biologicals Category Peptide Species Human

SENP3-Antibody-N-term-Blocking-Peptide - BP1234a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SENP3 Blocking Peptide - 33R-7268 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SENP3 Blocking Peptide - abx063804 from Abbexa Category Peptide Species Human, Monkey

SENP3 - H00026168-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SENP3 - H00026168-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

SENP3 - H00026168-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

SENP3 fusion protein - Ag11930 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SENP3 fusion protein - ag14284 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SENP3 fusion protein - ag11911 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SENP3 fusion protein - Ag14222 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SENP3, His-tagged - SENP3-2577H from Creative Biomart Category Protein Source E.coli Species Human

SENP3 Blocking Peptide - CBP2610 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

SENP3 (Y24) Peptide - BS1471P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Sentrin-specific protease 3(SENP3) - CSB-YP887980HU CSB-EP887980HU CSB-BP887980HU CSB-MP887980HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SENP3 Protein - NBP2-32525PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SENP3-Antibody-C-term-Blocking-Peptide - BP1235a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SENP3 Peptide, Human - M34GP14000H from Creative Peptides Category Peptide Source Synthetic. Species Human

Sentrin-specific protease 3 (SENP3), Recombinant Protein - MBS1468758 from MyBioSource Category Protein Prices $1,370.00, $1,370.00, $1,590.00, $1,590.00, $2,285.00, $2,285.00, $2,750.00, $2,750.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SENP3 peptide - orb218473 from Biorbyt Category Peptide

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