| Gene Symbol |
SENP3
|
| Entrez Gene |
26168
|
| Alt Symbol |
SMT3IP1, SSP3, Ulp1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUMO1/sentrin/SMT3 specific peptidase 3
|
| Other Description |
SUMO-1-specific protease 3|sentrin-specific protease 3|sentrin/SUMO-specific protease 3
|
| Swissprots |
Q96PS4 Q66K15 Q9H4L4 Q9Y3W9 Q86VS7
|
| Accessions |
EAW90170 EAW90171 EAW90172 Q9H4L4 AF199459 AAL25652 AK000923 AL050283 CAB43384 AL557688 AL834294 CAD38967 AM392699 CAL37577 AM392708 CAL37586 AY008763 AAG33252 BC048306 AAH48306 BC080658 AAH80658 BF514106 BQ424754 BQ956948 CX165088 NM_015670 NP_056485
|
| Function |
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859}
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.
|