| Gene Symbol |
SIN3B
|
| Entrez Gene |
23309
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SIN3 transcription regulator family member B
|
| Other Description |
SIN3 homolog B, transcriptional regulator|SIN3 transcription regulator homolog B|histone deacetylase complex subunit Sin3b|paired amphipathic helix protein Sin3b|transcriptional corepressor Sin3b
|
| Swissprots |
Q8TB34 Q9BSC8 Q6P4B8 O75182 Q2NL91 Q68GC2
|
| Accessions |
EAW84564 EAW84565 O75182 AB014600 BAA31675 AK001633 AK295618 BAH12128 AK311023 AY706204 AAU01916 BC005113 AAH05113 BC025026 AAH25026 BC063531 AAH63531 BC110821 AAI10822 BC172412 AAI72412 DB504745 DC332740 HY055983 XM_006722704 XP_006722767 NM_001297595 NP_001284524 NM_001297597 NP_001284526 NM_015260 NP_056075
|
| Function |
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810}.
|
![Western Blot: SIN3B Overexpression Lysate (Adult Normal) [NBP2-07193] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIN3B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1750_SIN3B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07193-img0001.jpg)