Gene Symbol | SIN3B |
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Entrez Gene | 23309 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | SIN3 transcription regulator family member B |
Other Description | SIN3 homolog B, transcriptional regulator|SIN3 transcription regulator homolog B|histone deacetylase complex subunit Sin3b|paired amphipathic helix protein Sin3b|transcriptional corepressor Sin3b |
Swissprots | Q8TB34 Q9BSC8 Q6P4B8 O75182 Q2NL91 Q68GC2 |
Accessions | EAW84564 EAW84565 O75182 AB014600 BAA31675 AK001633 AK295618 BAH12128 AK311023 AY706204 AAU01916 BC005113 AAH05113 BC025026 AAH25026 BC063531 AAH63531 BC110821 AAI10822 BC172412 AAI72412 DB504745 DC332740 HY055983 XM_006722704 XP_006722767 NM_001297595 NP_001284524 NM_001297597 NP_001284526 NM_015260 NP_056075 |
Function | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00810}. |
mSin3B CRISPR/Cas9 KO Plasmid (h) - sc-401638 from Santa Cruz Biotechnology
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mSin3B HDR Plasmid (h) - sc-401638-HDR from Santa Cruz Biotechnology
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mSin3B Double Nickase Plasmid (h) - sc-401638-NIC from Santa Cruz Biotechnology
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mSin3B Double Nickase Plasmid (h2) - sc-401638-NIC-2 from Santa Cruz Biotechnology
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mSin3B CRISPR Activation Plasmid (h) - sc-401638-ACT from Santa Cruz Biotechnology
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mSin3B CRISPR Activation Plasmid (h2) - sc-401638-ACT-2 from Santa Cruz Biotechnology
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mSin3B Lentiviral Activation Particles (h) - sc-401638-LAC from Santa Cruz Biotechnology
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mSin3B Lentiviral Activation Particles (h2) - sc-401638-LAC-2 from Santa Cruz Biotechnology
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mSin3B siRNA (h) - sc-35975 from Santa Cruz Biotechnology
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mSin3B shRNA Plasmid (h) - sc-35975-SH from Santa Cruz Biotechnology
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mSin3B shRNA (h) Lentiviral Particles - sc-35975-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU053471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19348 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19348 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09991 from Sigma-Aldrich
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SIN3B siRNA (Human) - CRH8169 from Cohesion Biosciences
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SIN3B - MBS8202207 from MyBioSource
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Human SIN3B siRNA - orb268671 from Biorbyt
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SIN3B shRNA Plasmid (Human) - CHH8169 from Cohesion Biosciences
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