| Gene Symbol |
DMP1
|
| Entrez Gene |
1758
|
| Alt Symbol |
ARHP, ARHR, DMP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dentin matrix acidic phosphoprotein 1
|
| Other Description |
dentin matrix protein 1
|
| Swissprots |
A1L4L3 Q13316 O43265
|
| Accessions |
AAA97602 EAX05996 EAX05997 Q13316 AI371158 BC130581 AAI30582 BC132865 AAI32866 H89203 HQ258290 ADR83044 U65378 AAB87728 U89012 AAC51332 XM_011531705 XP_011530007 XM_011531706 XP_011530008 NM_001079911 NP_001073380 NM_004407 NP_004398
|
| Function |
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. {ECO:0000269|PubMed:12615915}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12615915}. Cytoplasm {ECO:0000269|PubMed:12615915}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12615915}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
|
| Tissue Specificity |
Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
|
