DMP1

Gene Symbol DMP1
Entrez Gene 1758
Alt Symbol ARHP, ARHR, DMP-1
Species Human
Gene Type protein-coding
Description dentin matrix acidic phosphoprotein 1
Other Description dentin matrix protein 1
Swissprots A1L4L3 Q13316 O43265
Accessions AAA97602 EAX05996 EAX05997 Q13316 AI371158 BC130581 AAI30582 BC132865 AAI32866 H89203 HQ258290 ADR83044 U65378 AAB87728 U89012 AAC51332 XM_011531705 XP_011530007 XM_011531706 XP_011530008 NM_001079911 NP_001073380 NM_004407 NP_004398
Function May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. {ECO:0000269|PubMed:12615915}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12615915}. Cytoplasm {ECO:0000269|PubMed:12615915}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12615915}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Tissue Specificity Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.

DMP-1 RNAi - H00001758-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7312 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7312 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08395 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08395

DMP1 siRNA (Human) - CRH1221 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DMP1 - MBS8228076 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DMP1 (NM_004407.3) - SHH278833 from Creative biogene

Category siRNA
Species Reactivities Human

DMP1 shRNA Plasmid (Human) - CHH1221 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DMP1 miRNA 3'UTR clone - MiUTR3H-03786 from Creative biogene

Species Reactivities Human
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