| Gene Symbol |
SLC6A20
|
| Entrez Gene |
54716
|
| Alt Symbol |
SIT1, XT3, Xtrp3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 6 (proline IMINO transporter), member 20
|
| Other Description |
X transporter protein 3|neurotransmitter transporter RB21A|orphan transporter XT3|sodium- and chloride-dependent transporter XTRP3|sodium/imino-acid transporter 1|solute carrier family 6 (neurotransmitter transporter), member 20|transporter rB21A homolog
|
| Swissprots |
Q9NPQ2 Q8TF10 Q9NQ77 O75590 Q9NP91 A1A4F2
|
| Accessions |
CAB96872 EAW64747 EAW64748 Q9NP91 AF075260 AAC27755 AF125107 AAL75944 AJ276207 CAB99310 AJ276208 CAB99311 AL389979 CAB97535 BC036073 BC126197 AAI26198 BC136431 AAI36432 BC144087 AAI44088 DR006419 EL949345 HQ258580 ADR83334 XM_005265236 XP_005265293 XM_011533847 XP_011532149 XM_011533848 XP_011532150 NM_020208 NP_064593 NM_022405 NP_071800
|
| Function |
Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. {ECO:0000269|PubMed:15632147, ECO:0000269|PubMed:19033659}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Located in the apical brush border membrane of kidney proximal tubule cells. {ECO:0000250}.
|
| Tissue Specificity |
Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. {ECO:0000269|PubMed:19033659, ECO:0000269|PubMed:9932288}.
|
![Western Blot: SLC6A20 Overexpression Lysate (Adult Normal) [NBP2-06677] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC6A20.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1625_SLC6A20%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06677-img0001.jpg)