Gene Symbol | SLC6A20 |
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Entrez Gene | 54716 |
Alt Symbol | SIT1, XT3, Xtrp3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 6 (proline IMINO transporter), member 20 |
Other Description | X transporter protein 3|neurotransmitter transporter RB21A|orphan transporter XT3|sodium- and chloride-dependent transporter XTRP3|sodium/imino-acid transporter 1|solute carrier family 6 (neurotransmitter transporter), member 20|transporter rB21A homolog |
Swissprots | Q9NPQ2 Q8TF10 Q9NQ77 O75590 Q9NP91 A1A4F2 |
Accessions | CAB96872 EAW64747 EAW64748 Q9NP91 AF075260 AAC27755 AF125107 AAL75944 AJ276207 CAB99310 AJ276208 CAB99311 AL389979 CAB97535 BC036073 BC126197 AAI26198 BC136431 AAI36432 BC144087 AAI44088 DR006419 EL949345 HQ258580 ADR83334 XM_005265236 XP_005265293 XM_011533847 XP_011532149 XM_011533848 XP_011532150 NM_020208 NP_064593 NM_022405 NP_071800 |
Function | Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. {ECO:0000269|PubMed:15632147, ECO:0000269|PubMed:19033659}. |
Subcellular Location | Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Located in the apical brush border membrane of kidney proximal tubule cells. {ECO:0000250}. |
Tissue Specificity | Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. {ECO:0000269|PubMed:19033659, ECO:0000269|PubMed:9932288}. |
XTRP3 CRISPR/Cas9 KO Plasmid (h) - sc-406636 from Santa Cruz Biotechnology
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XTRP3 HDR Plasmid (h) - sc-406636-HDR from Santa Cruz Biotechnology
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XTRP3 Double Nickase Plasmid (h) - sc-406636-NIC from Santa Cruz Biotechnology
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XTRP3 Double Nickase Plasmid (h2) - sc-406636-NIC-2 from Santa Cruz Biotechnology
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XTRP3 CRISPR Activation Plasmid (h) - sc-406636-ACT from Santa Cruz Biotechnology
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XTRP3 CRISPR Activation Plasmid (h2) - sc-406636-ACT-2 from Santa Cruz Biotechnology
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XTRP3 Lentiviral Activation Particles (h) - sc-406636-LAC from Santa Cruz Biotechnology
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XTRP3 Lentiviral Activation Particles (h2) - sc-406636-LAC-2 from Santa Cruz Biotechnology
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XTRP3 siRNA (h) - sc-61815 from Santa Cruz Biotechnology
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XTRP3 shRNA Plasmid (h) - sc-61815-SH from Santa Cruz Biotechnology
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XTRP3 shRNA (h) Lentiviral Particles - sc-61815-V from Santa Cruz Biotechnology
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SLC6A20 RNAi - H00054716-R02 from Novus Biologicals
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MISSION® esiRNA - EHU070141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2451 from Sigma-Aldrich
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SLC6A20 siRNA (Human) - CRJ0184 from Cohesion Biosciences
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SLC6A20 RNAi - H00054716-R01 from Novus Biologicals
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SLC6A20 - MBS8239503 from MyBioSource
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Human SLC6A20 siRNA - orb270685 from Biorbyt
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SLC6A20 shRNA Plasmid (Human) - CHJ0184 from Cohesion Biosciences
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