| Gene Symbol |
MX1
|
| Entrez Gene |
4599
|
| Alt Symbol |
IFI-78K, IFI78, MX, MxA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MX dynamin-like GTPase 1
|
| Other Description |
interferon-induced GTP-binding protein Mx1|interferon-induced protein p78|interferon-inducible protein p78|interferon-regulated resistance GTP-binding protein MxA|myxoma resistance protein 1|myxovirus (influenza virus) resistance 1, interferon-inducible protein p78
|
| Swissprots |
D3DSI8 C9IYV7 Q96CI3 C9J8D6 B2RDA5 B3KU10 P20591 Q86YP5 C9JN19 C9JZS6 C9JN88 C9JUL1
|
| Accessions |
AAD43063 CAB90556 EAX09600 EAX09601 EAX09602 EAX09603 EAX09604 P20591 A00209 CAA00041 AK093008 BAC04017 AK096355 BAG53272 AK225885 AK315465 BAG37852 AY186254 AAO31807 BC014222 AAH14222 BC032602 AAH32602 BC052255 CB151486 DA351922 DA726666 EB388095 JF432729 ADZ15946 M30817 AAA36337 M33882 AAA36458 XM_005260978 XP_005261035 XM_005260979 XP_005261036 XM_005260980 XP_005261037 XM_005260981 XP_005261038 XM_005260982 XP_005261039 XM_011529568 XP_011527870 XM_011529569 XP_011527871 XM_011529570 XP_011527872 NM_001144925 NP_001138397 NM_001178046 NP_001171517 NM_001282920 NP_001269849 NM_002462 NP_002453
|
| Function |
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. {ECO:0000269|PubMed:11880649, ECO:0000269|PubMed:14687945, ECO:0000269|PubMed:14752052, ECO:0000269|PubMed:15047845, ECO:0000269|PubMed:15355513, ECO:0000269|PubMe
|
| Subcellular Location |
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region.
|
| Top Pathways |
Measles, Influenza A
|