MX1

Gene Symbol	MX1
Entrez Gene	4599
Alt Symbol	IFI-78K, IFI78, MX, MxA
Species	Human
Gene Type	protein-coding
Description	MX dynamin-like GTPase 1
Other Description	interferon-induced GTP-binding protein Mx1|interferon-induced protein p78|interferon-inducible protein p78|interferon-regulated resistance GTP-binding protein MxA|myxoma resistance protein 1|myxovirus (influenza virus) resistance 1, interferon-inducible protein p78
Swissprots	D3DSI8 C9IYV7 Q96CI3 C9J8D6 B2RDA5 B3KU10 P20591 Q86YP5 C9JN19 C9JZS6 C9JN88 C9JUL1
Accessions	AAD43063 CAB90556 EAX09600 EAX09601 EAX09602 EAX09603 EAX09604 P20591 A00209 CAA00041 AK093008 BAC04017 AK096355 BAG53272 AK225885 AK315465 BAG37852 AY186254 AAO31807 BC014222 AAH14222 BC032602 AAH32602 BC052255 CB151486 DA351922 DA726666 EB388095 JF432729 ADZ15946 M30817 AAA36337 M33882 AAA36458 XM_005260978 XP_005261035 XM_005260979 XP_005261036 XM_005260980 XP_005261037 XM_005260981 XP_005261038 XM_005260982 XP_005261039 XM_011529568 XP_011527870 XM_011529569 XP_011527871 XM_011529570 XP_011527872 NM_001144925 NP_001138397 NM_001178046 NP_001171517 NM_001282920 NP_001269849 NM_002462 NP_002453
Function	Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. {ECO:0000269|PubMed:11880649, ECO:0000269|PubMed:14687945, ECO:0000269|PubMed:14752052, ECO:0000269|PubMed:15047845, ECO:0000269|PubMed:15355513, ECO:0000269|PubMe
Subcellular Location	Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region.
Top Pathways	Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MX1 full length protein - ab114395 from Abcam Category Protein Source Wheat germ Species Human

Human MX1 full length protein - ab187486 from Abcam Category Protein Source E. coli Species Human

MX1 / MX Antibody Blocking Peptide - LS-E4008 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MxA/Mx1 Recombinant Protein - H00004599-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MX1-Antibody-Center-Blocking-Peptide - BP16234c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bovine MX1 protein - orb191080 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

MX1 protein (His tag) - 80R-3961 from Fitzgerald Category Protein Prices $375.00 Sizes 100 µg Source E.coli

Human Myxovirus Resistance 1 Protein - abx068184 from Abbexa Category Protein Source E.coli Species Human

MX1 (1-662, His-tag) - AR51646PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

MX1 (1-662, His-tag) - AR51646PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

MX1 - H00004599-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MX1 - H00004599-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Myxovirus Resistance 1 (MX1), Human - 20-9485 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Human

MX1 fusion protein - ag4692 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MX1 fusion protein - ag4862 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MX1 - MX1-26961TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse), His-tagged - MX1-603H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Myxovirus Resistance 1 (MX1) - RPL763Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Myxovirus Resistance 1 (MX1) - RPL763Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Myxovirus Resistance 1 (MX1) - RPL763Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Interferon-induced GTP-binding protein Mx1(MX1) - CSB-YP015249HU CSB-EP015249HU CSB-BP015249HU CSB-MP015249HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MX1, 1-662aa, Human, His tag, E.coli - ATGP2826 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

MX1 (transcript variant 2) - TP307418 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MX1 (transcript variant 1) - TP327878 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MxA/Mx1 Recombinant Protein Antigen - NBP1-83120PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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