| Gene Symbol |
SYNGAP1
|
| Entrez Gene |
8831
|
| Alt Symbol |
MRD5, RASA1, RASA5, SYNGAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synaptic Ras GTPase activating protein 1
|
| Other Description |
Ras GTPase-activating protein SynGAP|neuronal RasGAP|ras/Rap GTPase-activating protein SynGAP|synaptic Ras GTPase activating protein 1 homolog|synaptic Ras GTPase activating protein, 135kDa|synaptic Ras GTPase-activating protein 1
|
| Swissprots |
A8MQC4 A2BEL7 Q9UGE2 Q96PV0 Q8TCS2 A2BEL6 A2AB17
|
| Accessions |
CAA16161 EAX03735 EAX03736 EAX03737 EAX03738 Q96PV0 AK094225 AK124666 AK307888 AL713634 CAD28452 BC148357 AAI48358 BM354009 BX282051 CN412954 DA057307 NM_006772 NP_006763 NM_001130066
|
| Function |
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). {ECO:0000250}.
|