| Gene Symbol |
CYTH3
|
| Entrez Gene |
9265
|
| Alt Symbol |
ARNO3, GRP1, PSCD3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytohesin 3
|
| Other Description |
ARF nucleotide-binding site opener 3|PH, SEC7 and coiled-coil domain-containing protein 3|cytohesin-3|general receptor of phosphoinositides 1|pleckstrin homology, Sec7 and coiled-coil domains 3
|
| Swissprots |
A4D2N8 O43739
|
| Accessions |
AAS07510 EAL23717 EAW55046 O43739 AJ005197 CAA06434 AJ223957 CAA11686 AK023609 AK295163 BAH11995 AK313728 BAG36470 BC008191 AAH08191 BC028717 AAH28717 BG620295 CB988199 DQ891736 ABM82662 DQ894912 ABM85838 EU176610 ABW03411 NM_004227 NP_004218
|
| Function |
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}.
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
|
| Tissue Specificity |
Almost absent from liver, thymus and peripheral blood lymphocytes.
|
| Top Pathways |
Endocytosis
|