Gene Symbol | CYTH3 |
---|---|
Entrez Gene | 9265 |
Alt Symbol | ARNO3, GRP1, PSCD3 |
Species | Human |
Gene Type | protein-coding |
Description | cytohesin 3 |
Other Description | ARF nucleotide-binding site opener 3|PH, SEC7 and coiled-coil domain-containing protein 3|cytohesin-3|general receptor of phosphoinositides 1|pleckstrin homology, Sec7 and coiled-coil domains 3 |
Swissprots | A4D2N8 O43739 |
Accessions | AAS07510 EAL23717 EAW55046 O43739 AJ005197 CAA06434 AJ223957 CAA11686 AK023609 AK295163 BAH11995 AK313728 BAG36470 BC008191 AAH08191 BC028717 AAH28717 BG620295 CB988199 DQ891736 ABM82662 DQ894912 ABM85838 EU176610 ABW03411 NM_004227 NP_004218 |
Function | Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}. |
Subcellular Location | Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. |
Tissue Specificity | Almost absent from liver, thymus and peripheral blood lymphocytes. |
Top Pathways | Endocytosis |
GRP1 CRISPR/Cas9 KO Plasmid (h) - sc-407356 from Santa Cruz Biotechnology
|
||||||||
GRP1 HDR Plasmid (h) - sc-407356-HDR from Santa Cruz Biotechnology
|
||||||||
GRP1 Double Nickase Plasmid (h) - sc-407356-NIC from Santa Cruz Biotechnology
|
||||||||
GRP1 Double Nickase Plasmid (h2) - sc-407356-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GRP1 CRISPR Activation Plasmid (h) - sc-407356-ACT from Santa Cruz Biotechnology
|
||||||||
GRP1 CRISPR Activation Plasmid (h2) - sc-407356-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GRP1 Lentiviral Activation Particles (h) - sc-407356-LAC from Santa Cruz Biotechnology
|
||||||||
GRP1 Lentiviral Activation Particles (h2) - sc-407356-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GRP1 siRNA (h) - sc-40472 from Santa Cruz Biotechnology
|
||||||||
GRP1 shRNA Plasmid (h) - sc-40472-SH from Santa Cruz Biotechnology
|
||||||||
GRP1 shRNA (h) Lentiviral Particles - sc-40472-V from Santa Cruz Biotechnology
|
||||||||
Cytohesin 3 RNAi - H00009265-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU042341 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6901 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6901 from Sigma-Aldrich
|
||||||||
CYTH3 siRNA (Human) - CRH6135 from Cohesion Biosciences
|
||||||||
CYTH3 - MBS8231831 from MyBioSource
|
||||||||
shRNA set against Human CYTH3 (NM_004227.3) - SHH273929 from Creative biogene
|
||||||||
shRNA set against Human PSCD3(NM_004227.3) - SHR145400 from Creative biogene
|
||||||||
Human CYTH3 siRNA - orb266637 from Biorbyt
|
||||||||
CYTH3 shRNA Plasmid (Human) - CHH6135 from Cohesion Biosciences
|
||||||||
CYTH3 miRNA 3'UTR clone - MiUTR1H-08356 from Creative biogene
|