RAD50

Gene Symbol	RAD50
Entrez Gene	10111
Alt Symbol	NBSLD, RAD502, hRad50
Species	Human
Gene Type	protein-coding
Description	RAD50 homolog (S. cerevisiae)
Other Description	DNA repair protein RAD50
Swissprots	Q9UP86 Q92878 Q6GMT7 B9EGF5 Q6P5X3 O43254
Accessions	EAW62328 EAW62329 EAW62330 Q92878 AF057299 AAD50325 AF057300 AAD50326 AK290597 BAF83286 AK307439 BC062603 AAH62603 BC073850 AAH73850 BC108282 AAI08283 BC136436 AAI36437 BC140005 AAI40006 DB112912 DQ655928 U63139 AAB07119 NM_005732 NP_005723 NM_133482
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.
Subcellular Location	Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents.
Tissue Specificity	Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts. {ECO:0000269|PubMed:8756642}.
Top Pathways	Homologous recombination, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RAD50 Antibody Blocking Peptide - LS-E6470 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human RAD50 Protein - abx066358 from Abbexa Category Protein Source E.coli Species Human

Human RAD50 Protein - abx066357 from Abbexa Category Protein Source E.coli Species Human

RAD50 Blocking Peptide - abx063649 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

DNA Repair Protein RAD50 (RAD50), Human - 20-9417 from ARP American Research Products Category Protein Prices $609.00 Sizes 50 µg Source E.coli Species Human

DNA Repair Protein RAD50 (RAD50), Human - 20-9418 from ARP American Research Products Category Protein Prices $609.00 Sizes 50 µg Source E.coli Species Human

Recombinant DNA Repair Protein RAD50 (RAD50) - RPK111Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant DNA Repair Protein RAD50 (RAD50) - RPK111Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant DNA Repair Protein RAD50 (RAD50) - RPK111Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant DNA Repair Protein RAD50 (RAD50) - RPK111Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

RAD50 Blocking Peptide - CBP2455 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

Rad50 (A708) Peptide - BS2232P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA repair protein RAD50(RAD50) ,partial - CSB-YP838816HU CSB-EP838816HU CSB-BP838816HU CSB-MP838816HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rad50 Recombinant Protein Antigen - NBP2-47316PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RAD50 Blocking Peptide (OESA09475) - OESA09475 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

RAD50-Antibody-N-term-Blocking-Peptide - BP7360a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAD50 Peptide, Human - M34GP12910H from Creative Peptides Category Peptide Source Synthetic. Species Human

RAD50 peptide - orb218318 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

RAD50 Recombinant Protein (OPCD06573) - OPCD06573 from Aviva Systems Biology Category Protein Source E.coli Species Human

RAD50 Recombinant Protein (OPCD06575) - OPCD06575 from Aviva Systems Biology Category Protein Source E.coli Species Human

DNA Repair Protein RAD50, Recombinant Protein - MBS2031094 from MyBioSource Category Protein Prices $195.00, $410.00, $635.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

DNA Repair Protein RAD50 (RAD50), Recombinant Protein - MBS2009740 from MyBioSource Category Protein Prices $210.00, $475.00, $745.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

DNA Repair Protein RAD50 (RAD50), Recombinant Protein - MBS2010089 from MyBioSource Category Protein Prices $210.00, $475.00, $745.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

DNA repair protein RAD50 (RAD50), partial, Recombinant Protein - MBS1380674 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human RAD50 protein, His-tagged - RAD50-1744H from Creative Biomart Category Protein Source E. coli Species Human

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