RAD50

Gene Symbol	RAD50
Entrez Gene	10111
Alt Symbol	NBSLD, RAD502, hRad50
Species	Human
Gene Type	protein-coding
Description	RAD50 homolog (S. cerevisiae)
Other Description	DNA repair protein RAD50
Swissprots	Q9UP86 Q92878 Q6GMT7 B9EGF5 Q6P5X3 O43254
Accessions	EAW62328 EAW62329 EAW62330 Q92878 AF057299 AAD50325 AF057300 AAD50326 AK290597 BAF83286 AK307439 BC062603 AAH62603 BC073850 AAH73850 BC108282 AAI08283 BC136436 AAI36437 BC140005 AAI40006 DB112912 DQ655928 U63139 AAB07119 NM_005732 NP_005723 NM_133482
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.
Subcellular Location	Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents.
Tissue Specificity	Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts. {ECO:0000269|PubMed:8756642}.
Top Pathways	Homologous recombination, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse RAD50 ELISA Kit (Sandwich ELISA) - LS-F7951 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.27 ng/ml Range 0.781-50 ng/ml

Human RAD50 ELISA Kit (Sandwich ELISA) - LS-F9206 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.781-50 ng/ml

Rabbit anti-Rad50 Antibody, Affinity Purified - PLA0058 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

DNA Repair Protein RAD50 (RAD50), Human, ELISA Kit - SEK111Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

RAD50 homolog (S. cerevisiae) , ELISA Kit - MBS9329223 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Repair Protein RAD50 (RAD50), ELISA Kit - MBS2021902 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.057ng/mL. Range 0.156-10ng/mL

DNA Repair Protein RAD50 (RAD50), ELISA Kit - MBS2021316 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.27ng/mL. Range 0.781-50ng/mL

ELISA Kit for DNA Repair Protein RAD50 (RAD50) - SEK111Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DNA Repair Protein RAD50 (RAD50) - SEK111Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human RAD50 ELISA Kit - abx152916 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

DNA Repair Protein RAD50 (RAD50), Human, ELISA Kit - DL-RAD50-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human RAD50 ELISA Kit - abx571705 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human RAD50 ELISA Kit - E012160 from Biobool Category ELISA Kit Sensitivity Typically less than 0.057ng/mL.

RAD50 ELISA Kit (Human) (OKCD00590) - OKCD00590 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.057 ng/mL Range 0.156-10 ng/mL

RAD50 ELISA Kit (Human) (OKDD00499) - OKDD00499 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.057 ng/mL Range 0.156-10 ng/mL

anti-Rad50 antibody - ARG56277 from Arigo Biolaboratories Category ELISA Kit

DNA Repair Protein RAD50 (RAD50), ELISA Kit - MBS455047 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.057ng/mL Range 0.156-10ng/mL

DNA Repair Protein RAD50 (RAD50), ELISA Kit - MBS9370605 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA repair protein RAD50, ELISA Kit - MBS285317 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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