RAD50

Gene Symbol RAD50
Entrez Gene 10111
Alt Symbol NBSLD, RAD502, hRad50
Species Human
Gene Type protein-coding
Description RAD50 homolog (S. cerevisiae)
Other Description DNA repair protein RAD50
Swissprots Q9UP86 Q92878 Q6GMT7 B9EGF5 Q6P5X3 O43254
Accessions EAW62328 EAW62329 EAW62330 Q92878 AF057299 AAD50325 AF057300 AAD50326 AK290597 BAF83286 AK307439 BC062603 AAH62603 BC073850 AAH73850 BC108282 AAI08283 BC136436 AAI36437 BC140005 AAI40006 DB112912 DQ655928 U63139 AAB07119 NM_005732 NP_005723 NM_133482
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.
Subcellular Location Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents.
Tissue Specificity Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts. {ECO:0000269|PubMed:8756642}.
Top Pathways Homologous recombination, Non-homologous end-joining

Rad50 CRISPR/Cas9 KO Plasmid (h) - sc-401617 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 HDR Plasmid (h) - sc-401617-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 Double Nickase Plasmid (h) - sc-401617-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 Double Nickase Plasmid (h2) - sc-401617-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 CRISPR Activation Plasmid (h) - sc-401617-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 CRISPR Activation Plasmid (h2) - sc-401617-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 Lentiviral Activation Particles (h) - sc-401617-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 Lentiviral Activation Particles (h2) - sc-401617-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rad50 siRNA (h) - sc-37397 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad50 shRNA Plasmid (h) - sc-37397-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad50 shRNA (h) Lentiviral Particles - sc-37397-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rad50 RNAi - H00010111-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU051721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2308 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2308 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10201 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10201

RAD50 siRNA (Human) - CRH6817 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Rad50 RNAi - H00010111-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RAD50 - MBS8208784 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RAD50 (NM_005732.3) - SHH388984 from Creative biogene

Category siRNA
Species Reactivities Human

Human RAD50 siRNA - orb267319 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAD50 shRNA Plasmid (Human) - CHH6817 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RAD50 miRNA 3'UTR clone - MiUTR3H-06460 from Creative biogene

Species Reactivities Human
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