| Gene Symbol |
RASSF7
|
| Entrez Gene |
8045
|
| Alt Symbol |
C11orf13, HRAS1, HRC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
|
| Other Description |
HRAS1-related cluster protein 1|HRAS1-related cluster-1|Ras association (RalGDS/AF-6) domain family 7|ras association domain-containing protein 7
|
| Swissprots |
G5E9N9 Q3KP42 Q3KP41 Q02833
|
| Accessions |
EAX02348 EAX02349 EAX02350 EAX02351 Q02833 AL535761 BC106921 AAI06922 BC106922 AAI06923 CA315057 EU446739 ABZ92268 M91083 AAA58667 XM_005253147 XP_005253204 XM_005253148 XP_005253205 XM_005253149 XP_005253206 XM_005253150 XP_005253207 XM_005253151 XP_005253208 XM_006718338 XP_006718401 XM_006725142 XP_006725205 XM_006725143 XP_006725206 XM_006725144 XP_006725207 XM_006725145 XP_006725208 XM_011520388 XP_011518690 XM_011520389 XP_011518691 XM_011546611 XP_011544913 NM_001143993 NP_001137465 NM_001143994 NP_001137466 NM_003475 NP_003466
|
| Function |
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269|PubMed:20629633, ECO:0000269|PubMed:21278800}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
|