Gene Symbol | RASSF7 |
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Entrez Gene | 8045 |
Alt Symbol | C11orf13, HRAS1, HRC1 |
Species | Human |
Gene Type | protein-coding |
Description | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 |
Other Description | HRAS1-related cluster protein 1|HRAS1-related cluster-1|Ras association (RalGDS/AF-6) domain family 7|ras association domain-containing protein 7 |
Swissprots | G5E9N9 Q3KP42 Q3KP41 Q02833 |
Accessions | EAX02348 EAX02349 EAX02350 EAX02351 Q02833 AL535761 BC106921 AAI06922 BC106922 AAI06923 CA315057 EU446739 ABZ92268 M91083 AAA58667 XM_005253147 XP_005253204 XM_005253148 XP_005253205 XM_005253149 XP_005253206 XM_005253150 XP_005253207 XM_005253151 XP_005253208 XM_006718338 XP_006718401 XM_006725142 XP_006725205 XM_006725143 XP_006725206 XM_006725144 XP_006725207 XM_006725145 XP_006725208 XM_011520388 XP_011518690 XM_011520389 XP_011518691 XM_011546611 XP_011544913 NM_001143993 NP_001137465 NM_001143994 NP_001137466 NM_003475 NP_003466 |
Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269|PubMed:20629633, ECO:0000269|PubMed:21278800}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin. |
RASSF7 CRISPR/Cas9 KO Plasmid (h) - sc-407740 from Santa Cruz Biotechnology
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RASSF7 HDR Plasmid (h) - sc-407740-HDR from Santa Cruz Biotechnology
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RASSF7 Double Nickase Plasmid (h) - sc-407740-NIC from Santa Cruz Biotechnology
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RASSF7 Double Nickase Plasmid (h2) - sc-407740-NIC-2 from Santa Cruz Biotechnology
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RASSF7 CRISPR Activation Plasmid (h) - sc-407740-ACT from Santa Cruz Biotechnology
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RASSF7 CRISPR Activation Plasmid (h2) - sc-407740-ACT-2 from Santa Cruz Biotechnology
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RASSF7 Lentiviral Activation Particles (h) - sc-407740-LAC from Santa Cruz Biotechnology
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RASSF7 Lentiviral Activation Particles (h2) - sc-407740-LAC-2 from Santa Cruz Biotechnology
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RASSF7 siRNA (h) - sc-96878 from Santa Cruz Biotechnology
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RASSF7 shRNA Plasmid (h) - sc-96878-SH from Santa Cruz Biotechnology
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RASSF7 shRNA (h) Lentiviral Particles - sc-96878-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18001 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03710 from Sigma-Aldrich
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RASSF7 siRNA (Human) - CRH5351 from Cohesion Biosciences
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RASSF7 RNAi - H00008045-R01 from Novus Biologicals
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RASSF7 - MBS8240557 from MyBioSource
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shRNA set against Human RASSF7 (NM_003475.3) - SHH390224 from Creative biogene
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Human RASSF7 siRNA - orb265853 from Biorbyt
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RASSF7 shRNA Plasmid (Human) - CHH5351 from Cohesion Biosciences
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RASSF7 miRNA 3'UTR clone - MiUTR3H-01117 from Creative biogene
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RASSF7 miRNA 3'UTR clone - MiUTR3H-01118 from Creative biogene
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RASSF7 miRNA 3'UTR clone - MiUTR3H-01119 from Creative biogene
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