COPS5

Gene Symbol	COPS5
Entrez Gene	10987
Alt Symbol	CSN5, JAB1, MOV-34, SGN5
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 5
Other Description	38 kDa Mov34 homolog|COP9 constitutive photomorphogenic homolog subunit 5|COP9 signalosome complex subunit 5|jun activation domain-binding protein 1|signalosome subunit 5
Swissprots	Q9BQ17 Q86WQ4 O15386 Q92905 Q6AW95
Accessions	CBH51784 EAW86928 EAW86929 EAW86930 EAW86931 Q92905 AA203444 AB209134 BAD92371 AK056967 AK128519 AK310434 AK311071 BC001187 AAH01187 BC001859 AAH01859 BC007272 AAH07272 BI752436 BX648542 CAH10375 CR541678 CAG46479 JF432439 ADZ15656 U65928 AAB16847 U70734 AAD03468 NM_006837 NP_006828
Function	Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key rol
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human COPS5 / JAB1 ELISA Kit (Cell-Based ELISA) - LS-F3272 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

COP9 signalosome complex subunit 5 (COPS5), Human, ELISA Kit - E01C1940 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

COPS5 Colorimetric Cell-Based ELISA - CB6102 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7222529 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7202566 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7245074 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7214116 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7253629 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7243646 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7226508 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7232923 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7228344 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7225565 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7209705 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 5 (COPS5), ELISA Kit - MBS7245300 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

JAB1 ELISA Kit - DEIA-XYA1069 from Creative Diagnostics Category ELISA Kit

COPS5 ELISA Kit - DEIA-XYA449 from Creative Diagnostics Category ELISA Kit

Human COPS5 ELISA Kit - E080299 from Biobool Category ELISA Kit

anti-JAB1 antibody - ARG53162 from Arigo Biolaboratories Category ELISA Kit

anti-JAB1 antibody (Ready-to-Use) - ARG53163 from Arigo Biolaboratories Category ELISA Kit

JAB1 Colorimetric Cell-Based ELISA Kit - EKA50328 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

COPS5 Colorimetric Cell-Based ELISA Kit - EKA50923 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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