| Gene Symbol |
COPS5
|
| Entrez Gene |
10987
|
| Alt Symbol |
CSN5, JAB1, MOV-34, SGN5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COP9 signalosome subunit 5
|
| Other Description |
38 kDa Mov34 homolog|COP9 constitutive photomorphogenic homolog subunit 5|COP9 signalosome complex subunit 5|jun activation domain-binding protein 1|signalosome subunit 5
|
| Swissprots |
Q9BQ17 Q86WQ4 O15386 Q92905 Q6AW95
|
| Accessions |
CBH51784 EAW86928 EAW86929 EAW86930 EAW86931 Q92905 AA203444 AB209134 BAD92371 AK056967 AK128519 AK310434 AK311071 BC001187 AAH01187 BC001859 AAH01859 BC007272 AAH07272 BI752436 BX648542 CAH10375 CR541678 CAG46479 JF432439 ADZ15656 U65928 AAB16847 U70734 AAD03468 NM_006837 NP_006828
|
| Function |
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key rol
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.
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