COPS5

Gene Symbol COPS5
Entrez Gene 10987
Alt Symbol CSN5, JAB1, MOV-34, SGN5
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 5
Other Description 38 kDa Mov34 homolog|COP9 constitutive photomorphogenic homolog subunit 5|COP9 signalosome complex subunit 5|jun activation domain-binding protein 1|signalosome subunit 5
Swissprots Q9BQ17 Q86WQ4 O15386 Q92905 Q6AW95
Accessions CBH51784 EAW86928 EAW86929 EAW86930 EAW86931 Q92905 AA203444 AB209134 BAD92371 AK056967 AK128519 AK310434 AK311071 BC001187 AAH01187 BC001859 AAH01859 BC007272 AAH07272 BI752436 BX648542 CAH10375 CR541678 CAG46479 JF432439 ADZ15656 U65928 AAB16847 U70734 AAD03468 NM_006837 NP_006828
Function Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key rol
Subcellular Location Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

COPS5 Antibody - 6895 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using COPS5 Antibody.

COPS5 (D15G6) Rabbit mAb - 9444 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D15G6
Western blot analysis of extracts from various cell lines using COPS5 (D15G6) Rabbit mAb.

JAB1 (B-7) - sc-13157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAB1 (B-7): sc-13157. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tumor showing nuclear staining.

JAB1 (G-10) - sc-393725 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAB1 (G-10): sc-393725. Western blot analysis of JAB1 expression in Caki-1 (A), HeLa (B), Jurkat (C) and U-87 MG (D) whole cell lysates and rat liver (E) and human liver (F) tissue extracts.

JAB1 (42) - sc-135954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
JAB1 (42): sc-135954. Western blot analysis of JAB1 expression in Jurkat whole cell lysate.

JAB1 (FL-334) - sc-9074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAB1 (FL-334): sc-9074. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tumor (A) and immunofluorescence staining of methanol-fixed KNRK cells (B) showing nuclear localization.

JAB1 (N-17) - sc-6271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JAB1 (N-17): sc-6271. Western blot analysis of JAB1 expression in mouse embryo (A) and rat liver (B) extracts.

Anti-JAB1 antibody - ab12323 from Abcam

Prices $380.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma (left) and mouse teratoma (right) tissues labelling JAB1 with ab12323 at 1/500 (2µg/ml). Detection: DAB.

Anti-JAB1 antibody - ab137326 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells labelling JAB1, using ab137326 (green) at a 1/100 dilution. Cell nuclei were stained with Hoechst 33342 (blue).

Anti-JAB1 antibody - ab182756 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling JAB1 with ab182756 at 1/120 dilution (left panel). Right panel was treated with the immunogen.

Anti-JAB1 antibody - ab12184 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JAB1 antibody - ab74271 from Abcam

Prices $370.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Formalin fixed/paraffin embedded uman breast carcinoma tissue stained with 1/200 ab74271 (30mins, RT).

Anti-JAB1 antibody - ab53768 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JAB1 antibody (ab53768) at 1/500 dilutionLane 1 : Extracts from LOVO cellsLane 2 : Extracts from LOVO cells, plus peptide

Anti-JAB1 antibody - ab69584 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JAB1 antibody (ab69584) at 1/500 dilutionLane 1 : extracts from 293 cells Lane 2 : extracts from K562 cells Lane 3 : extracts from 293 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-JAB1 antibody [2A10] - ab495 from Abcam

Prices $380.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2A10
IHC image of ab495 staining in human breast carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab495, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-JAB1 antibody [2A10.8] - ab115610 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2A10.8
ab115610, at 5µg/ml, staining Brain, Cerebellum in Formalin-fixed, Paraffin-embedded Human Brain Cerebellum tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-JAB1 antibody [6C3] - ab496 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C3

Anti-JAB1 antibody [6C3.38] - ab118841 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6C3.38
ab118841, at 5 µg/ml, staining JAB1 in Formalin-fixed, Paraffin-embedded Human brain, cerebellum tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-JAB1 antibody [EPR1350] - ab124720 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1350
All lanes : Anti-JAB1 antibody [EPR1350] (ab124720) at 1/1000 dilutionLane 1 : NIH 3T3 cell lysateLane 2 : U87-MG cell lysateLane 3 : MCF7 cell lysateLane 4 : PC12 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-JAB1 antibody, prediluted - ab37290 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Ab37290 staining human JAB1 in breast carcinoma by immunohistochemistry with formalin fixed, paraffin embedded tissue.

Anti-COPS5 / JAB1 Antibody (aa318-334) - LS-C313359 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
WB of COPS5 / JAB1 antibody. All lanes: Anti-COPS5 at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Lane 2: NIH Whole Cell Lysate at 40ug. Lane 3: HELA Whole Cell Lysate at 40ug. Predicted bind size: 38KD. Observed bind size: 38KD.

Anti-COPS5 / JAB1 Antibody (clone 6C3.38) IHC-plus™ - LS-B1690 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 6C3.38
Anti-COPS5 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1690 concentration 5 ug/ml.

Anti-COPS5 / JAB1 Antibody (aa175-225) - LS-C286958 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse CSN5 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-CSN5 used at a dilution of 1:500 (2 ug/ml). Detection: DAB.

Anti-COPS5 / JAB1 Antibody (clone 2A10.8) IHC-plus™ - LS-B1689 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2A10.8
Anti-COPS5 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1689 concentration 5 ug/ml.

Anti-COPS5 / JAB1 Antibody (Internal) IHC-plus™ - LS-B2553 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Anti-COPS5 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2553 concentration 10 ug/ml.
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