| Gene Symbol |
CRTC3
|
| Entrez Gene |
64784
|
| Alt Symbol |
TORC-3, TORC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CREB regulated transcription coactivator 3
|
| Other Description |
CREB-regulated transcription coactivator 3|transducer of regulated CREB protein 3|transducer of regulated cAMP response element-binding protein (CREB) 3|transducer of regulated cAMP response element-binding protein 3
|
| Swissprots |
Q6UUV7 Q6DK61 Q6DK62 Q9H6U2 Q8NF38
|
| Accessions |
Q6UUV7 AI969212 AK024981 AK025521 BAB15160 AK074170 BAB84996 AK090443 BAC03424 AK225300 AL360259 AY360173 AAQ98858 BC019060 BC074730 AAH74730 BC074731 AAH74731 BP238198 BP365179 BQ945777 CN298837 DB288138 HY057135 HY109267 HY180993 XM_005254968 XP_005255025 XM_011521906 XP_011520208 NM_001042574 NP_001036039 NM_022769 NP_073606
|
| Function |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
|
| Tissue Specificity |
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:16980408}.
|
| Top Pathways |
HTLV-I infection
|